Protein Information

General Information
MoonProt ID100
First appeared in release1.0
Name(s)Triose phosphate isomerase TIM Triose-phosphate isomerase tpiA Gene Name: tpi
UniProt IDQ6GIL6
GO termsGO:0006094 gluconeogenesis GO:0006096 glycolysis GO:0006098 pentose-phosphate shunt GO:0098631 cell adhesion mediator activity GO:0008152 metabolic process GO:0003824 catalytic activity GO:0004807 triose-phosphate isomerase activity GO:0016853 isomerase activity GO:0005737 cytoplasm
Organisms for which functions have been demonstratedStaphylococcus aureus
Sequence length253 aa
FASTA sequence>sp|Q6GIL6|TPIS_STAAR Triosephosphate isomerase OS=Staphylococcus aureus (strain MRSA252) GN=tpiA PE=1 SV=1 MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK
Structure Information
PDB ID3M9Y 3UWU 3UWV 3UWW 3UWZ
Quaternary structure
Function 1
Function descriptionTriose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation, glycolysis Carbohydrate biosynthesis, gluconeogenesis
References for function
E.C. number5.3.1.1
Location of functional site(s)Active site:169,97 Binding site:215,175
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin, contact-mediated killing of Cryptococcus
References for functionYamaguchi M, Ikeda R, Nishimura M, Kawamoto S. Localization by scanning immunoelectron microscopy of triosephosphate isomerase, the molecules responsible for contact-mediated killing of Cryptococcus, on the surface of Staphylococcus. Microbiol Immunol. 2010 Jun. PMID: 20536736
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments