Protein Information

General Information
MoonProt ID11
First appeared in release1.0
Name(s)40S ribosomal protein S3 Gene Name:RPS3
UniProt IDP23396 (RS3_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000737 DNA catabolic process, endonucleolytic GO:0002181 cytoplasmic translation GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006974 cellular response to DNA damage stimulus GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0044267 cellular protein metabolic process GO:0045738 negative regulation of DNA repair GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:1902546 positive regulation of DNA N-glycosylase activity GO:2001235 positive regulation of apoptotic signaling pathway GO:0003684 damaged DNA binding GO:0003723 RNA binding GO:0003729 mRNA binding GO:0003735 structural constituent of ribosome GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0004519 endonuclease activity GO:0005515 protein binding GO:0019899 enzyme binding GO:0019901 protein kinase binding GO:0044822 poly(A) RNA binding GO:0051018 protein kinase A binding GO:0051059 NF-kappaB binding GO:0051536 iron-sulfur cluster binding GO:0005622 intracellular GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005840 ribosome GO:0015935 small ribosomal subunit GO:0022627 cytosolic small ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0032587 ruffle membrane GO:0070062 extracellular vesicular exosome colocalizes_with GO:0071159 NF-kappaB complex GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length243
FASTA sequence>sp|P23396|RS3_HUMAN 40S ribosomal protein S3 OS=Homo sapiens GN=RPS3 PE=1 SV=2 MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA
Structure Information
PDB ID2ZKQ, 3J3A, 4KZX, 4KZY, 4KZZ
Quaternary structure
Function 1
Function descriptionribosomal protein, part of the 40S subunit
References for functionKelley, Mark R., et al. "The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents." Mutation Research/DNA Repair485.2 (2001): 107-119.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiona subunit of a DNA binding complex involved in NF-kappaB-mediated transcription
References for functionWan F, Anderson DE, Barnitz RA, Snow A, Bidere N, Zheng L, Hegde V, Lam LT, Staudt LM, Levens D, Deutsch WA, Lenardo MJ. Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell. 2007 Nov 30. PMID: 18045535
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, nucleus
Comments
Third Function
Function descriptionstimulates activity of uracil-DNA glycosylase
References for functionKo SI, Park JH, Park MJ, Kim J, Kang LW, Han YS. Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase (hUNG) and stimulates its glycosylase activity. Mutat Res. 2008 Dec 15. PMID: 18973764
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments