Protein Information

General Information
MoonProt ID110
First appeared in release1.0
Name(s)aconitase aconitate hydratase Gene Name: acn
UniProt IDA0A0H3L8I8
GO termsGO:0008152 metabolic process GO:0003994 aconitate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0051536 iron-sulfur cluster binding GO:0003729 mRNA binding translation
Organisms for which functions have been demonstratedMycobacterium tuberculosis
Sequence length938 aa
FASTA sequence>tr|A0A0H3L8I8|A0A0H3L8I8_MYCTE Aconitate hydratase OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) GN=acn PE=4 SV=1 MNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLAENLLRNEDGSNITKDHIEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPDKVNPLAPADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVPPGTGIVHQVNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVGKFVEFYGEGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALVEAYAKAQGMWHDPKHEPEFSEYLELNLSDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGSPDSPHDPHSKLDEVVEETFPASDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKSDELGEFVLDHGAVVIAAITSCTNTSNPEVMLGAALLARNAVEKGLTSKPWVKTTIAPGSQVVNDYYDRSGLWPYLEKLGFYLVGYGCTTCIGNSGPLPEEISKAVNDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVIAYALAGTMDFDFQTQPLGQDKDGKNVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFKGDDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGMTAKPEPVGNISGARVLALLGDSVTTDHISPAGAIKPGTPAARYLDEHGVDRKDYNSFGSRRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIYDAAQNYAAQHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAVIAESFERIHRSNLIGMGVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQATKGDGATIEFDAVVRIDTPGEADYYRNGGILQYVLRNILKSG
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionaconitase, enzyme catalyse the isomerization of citrate to iso-citrate in the citric acid cycle
References for functionTian, Jing, et al. "Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase." Proceedings of the National Academy of Sciences of the United States of America 102.30 (2005): 10670-10675.
E.C. number4.2.1.3
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioniron-responsive protein Binds to selected IREs (Iron-responsive elements)--sequences present within the UTR (untranslated regions) of M. tuberculosis mRNA
References for functionS. Banerjee, A.K. Nandyala, P. Raviprasad, et al. (2007) Iron-Dependent RNA-Binding Activity of Mycobacterium tuberculosis Aconitase. J Bacteriol. 2007 Jun;189(11):4046-52. Epub 2007 Mar 23. PMID: 17384188
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments