Protein Information

General Information
MoonProt ID111
First appeared in release1.0
Name(s)aconitase Aconitate hydratase Homocitrate dehydratase Aconitase 2 Gene Name: ACO2
UniProt IDP39533 (ACON2_YEAST), Reviewed
GO termsGO:0006099 tricarboxylic acid cycle GO:0008150 biological_process GO:0008152 metabolic process GO:0008652 cellular amino acid biosynthetic process GO:0009085 lysine biosynthetic process GO:0019878 lysine biosynthetic process via aminoadipic acid GO:0003994 aconitate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0051536 iron-sulfur cluster binding GO:0051539 4 iron, 4 sulfur cluster binding GO:0005739 mitochondrion GO:0000002 mitochondrial genomw maintainance
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length789
FASTA sequence>sp|P39533|ACON2_YEAST Homocitrate dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO2 PE=1 SV=1 MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDKIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAINYIGNIRRNE
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionaconitase, enzyme Catalyzes the conversion of citrate to aconitate in the pathway for lysine biosynthesis. Krebs cycle, Amino-acid biosynthesis, L-lysine biosynthesis
References for function
E.C. numberEC=4.2.1.-
Location of functional site(s)Binding site:481,476,96 Metal binding site:451,385,448
Cellular location of functionmitochondrion
Comments
Function 2
Function descriptionmitochondrial DNA maintenance enzymatic activity and iron sulfur cluster are not needed for this role
References for functionX.J. Chen, X. Wang, B.A. Kaufman, et al. (2005) Aconitase Couples Metabolic Regulation to Mitochondrial DNA maintenance. Science. 2005 Feb 4;307(5710):714-7. PMID: 15692048
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrion
Comments