Protein Information

General Information
MoonProt ID114
First appeared in release1.0
Name(s)Argininosuccinate lyase ASAL ASL Arginosuccinase Delta Crystallin II Delta-2 Crystallin Gene Name: ASL2
UniProt IDP24058 (ARLY2_ANAPL), Reviewed
GO termsGO: 0006526 arginine biosynthetic process GO: 0008652 cellular amino acid biosynthetic process GO: 0042450 arginine biosynthetic process via ornithine GO: 0003824 catalytic activity GO: 0004056 argininosuccinate lyase activity GO: 0005212 structural constituent of eye lens GO: 0016829 lyase activity GO: 0005212 structural constituent of eye lens
Organisms for which functions have been demonstratedAnas platyrhynchos (duck)
Sequence length468
FASTA sequence>sp|P24058|ARLY2_ANAPL Argininosuccinate lyase OS=Anas platyrhynchos GN=ASL2 PE=1 SV=4 MASEARGDKLWGGRFSGSTDPIMEKLNSSIAYDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIHTANERRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAGNPLDIDREMLRSELEFASISLNSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFGFLTLSDAFSTGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQEDKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKALTPEMLATDLALYLVRKGVPFRQAHTASGKAVHLAETKGITINKLSLEDLKSISPQFSSDVSQVFNFVNSVEQYTALAGTAKSSVTTQIEQLRELMKKQKEQA
Structure Information
PDB ID1TJU 1TJV 1K7W 1AUW 1DCN
Quaternary structure
Function 1
Function descriptionArgininosuccinate lyase, enzyme Catalyzes the breakdown of argininosuccinate to produce arginine and fumarate. It is the fourth enzyme of the urea cycle. Argininosuccinase is involved in biosythesis of arginine in all species and production of urea in ureotelic organisms. 2-(N(omega)-L-arginino)succinate => fumarate + L-arginine Amino-acid biosynthesis, arginine biosynthesis
References for functionWistow, Graeme J., and Joram Piatigorsky. "Gene conversion and splice-site slippage in the argininosuccinate lyases/delta-crystallins of the duck lens: members of an enzyme superfamily." Gene 96.2 (1990): 263-270.
E.C. number4.3.2.1
Location of functional site(s)Active site:283,162,296 Binding site:29,328,323,161,331,289,91
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionDelta-2 Crystallin in the lens of the eye - only in birds and reptiles
References for functionWistow G, Piatigorsky J. (1987) Recruitment of enzymes as lens structural proteins. Science. 1987 Jun 19;236(4808):1554-6.6. PMID: 3589669
E.C. numberN/A
Location of functional site(s)
Cellular location of functionlens of eye
Comments