Protein Information

General Information
MoonProt ID118
First appeared in release1.0
Name(s)Aldehyde dehydrogenase, cytosolic 1 ALDH class 1 eta-crystallin Gene Name: ALDH1
UniProt IDQ28399 (ALDH1_ELEED) Reviewed
GO termsGO:0006068 ethanol catabolic process GO:0008152 metabolic process GO:0055114 oxidation-reduction process GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0005737 cytoplasm GO: 0005212 structural constituent of eye lens
Organisms for which functions have been demonstratedElephantus edwardii (elephant shrew)
Sequence length501
FASTA sequence>sp|Q28399|ALDH1_ELEED Aldehyde dehydrogenase, cytosolic 1 OS=Elephantulus edwardii GN=ALDH1 PE=1 SV=1 MSSSGMPDLPAPLTNIKIQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDVDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYLMDLDYCIKALRYCAGWADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIMELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGEYGIHEYTEVKTVTMKISEKNS
Structure Information
PDB ID1O9J
Quaternary structure
Function 1
Function descriptionretinaldehyde dehydrogenase, enzyme an aldehyde dehydrogenase class 1 An aldehyde + NAD+ + H2O => a carboxylate + NADH. Alcohol metabolism, ethanol degradation
References for functionBateman OA, Purkiss AG, van Montfort, Slingsby C, Graham C, Wistow G. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry. 2003 Apr 22. PMID: 12693930
E.C. number1.2.1.3
Location of functional site(s)Active site:303,269 Nucleotide binding site:246-251 Other functional site:170
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioneta crystallin
References for functionBateman OA, Purkiss AG, van Montfort, Slingsby C, Graham C, Wistow G. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry. 2003 Apr 22. PMID: 12693930
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm of eye lens
Comments