Protein Information

General Information
MoonProt ID12
First appeared in release1.0
Name(s)6-phosphogluconate dehydrogenase Gene Name: gnd
UniProt IDA0A0H2UNG6
GO termsGO:0006098 pentose-phosphate shunt GO:0019521 D-gluconate metabolic process GO:0055114 oxidation-reduction process GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GO:0016491 oxidoreductase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0050661 NADP binding GO:0050662 coenzyme binding GO: 0098631 cell adhesion mediator activity
Organisms for which functions have been demonstratedStreptococcus pneumoniae
Sequence length474
FASTA sequence>tr|A0A0H2UNG6|A0A0H2UNG6_STRPN 6-phosphogluconate dehydrogenase, decarboxylating OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=gnd PE=3 SV=1 MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFNFEGDKAELIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK
Structure Information
PDB IDclosest homologue with a structure in the PDB has 74% amino acid sequence identity
Quaternary structure
Function 1
Function description6-phosphogluconate dehydrogenase, enzyme 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH Carbohydrate degradation, pentose phosphate pathway
References for functionMartinez-Drets, G., A. Gardiol, and A. Arias. "6-Phospho-D-gluconate: NAD+ 2-oxidoreductase (decarboxylating) from slow-growing Rhizobia." Journal of bacteriology 130.3 (1977): 1139-1143.
E.C. number1.1.1.44
Location of functional site(s)Active site:191,184 Binding site:290,455,449,192,102,263 Nucleotide binding site:10-15,33-35,74-76
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin - not clear to which host protein
References for functionDaniely D, Portnoi M, Shagan M, Porgador A, Givon-Lavi N, Ling E, Dagan R, Mizrachi Nebenzahl Y (2006) Pneumococcal 6-phosphogluconate-dehydrogenase, a putative adhesin, induces protective immune response in mice. Clin Exp Immunol 144:254263. PMID: 16634799
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Commentsinhibit bacterial adhesion to A459 type II lung carcinoma cells, anti-r6PGD-antibodies inhibited 90% of S. pneumoniae adhesion to the cultured cells in a concentration-dependent manner - from Daniely D, Portnoi M, Shagan M, Porgador A, Givon-Lavi N, Ling E, Dagan R, Mizrachi Nebenzahl Y (2006) Pneumococcal 6-phosphogluconate-dehydrogenase, a putative adhesin, induces protective immune response in mice. Clin Exp Immunol 144:254263