Protein Information

General Information
MoonProt ID125
First appeared in release1.0
Name(s)Albaflavenone Monooxygenase Albaflavenone synthase CYP170A1 Cytochrome P450 Epi-isozizaene 5-monooxygenase/(E)-beta-fernesene synthase terpene synthase Cytochrome P450 170A1
UniProt IDQ9K498 (EIZFM_STRCO), Reviewed
GO termsGO:0055114 oxidation-reduction process GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0010333 terpene synthase activity GO:0016491 oxidoreductase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016829 lyase activity GO:0020037 heme binding GO:0046872 metal ion binding GO:0010333 terpene synthase activity
Organisms for which functions have been demonstratedstreptomyces coelicolor A3(2)
Sequence length461
FASTA sequence>sp|Q9K498|EIZFM_STRCO Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) GN=SCO5223 PE=1 SV=1 MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR
Structure Information
PDB ID3DBG 3EL3
Quaternary structure
Function 1
Function descriptionAlbaflavenone Monooxygenase (+)-epi-isozizaene + 2 NADPH + 2 O(2) <=> albaflavenone + 2 NADP(+) + 3 H(2)O
References for functionZhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J Biol Chem. 2008 Mar 28. PMID: 18234666
E.C. number1.14.13.106
Location of functional site(s)Metal binding site:410
Cellular location of function
Comments
Function 2
Function descriptionTerpene synthase (2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate
References for functionZhao B, Lei L, Vassylyev DG, Lin X, Cane DE, Kelly SL, Yuan H, Lamb DC, Waterman MR. Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. J Biol Chem. 2009 Dec 25. PMID: 19858213
E.C. number4.2.3.47
Location of functional site(s)
Cellular location of function
Comments