Protein Information

General Information
MoonProt ID134
First appeared in release1.0
Name(s)Transcriptional regulator URE2 Disulfide reductase Glutathione peroxidase Gene Name:URE2
UniProt IDP23202 (URE2_YEAST), Reviewed
GO termsGO:0006808 regulation of nitrogen utilization GO:0010044 response to aluminum ion GO:0032447 protein urmylation GO:0042128 nitrate assimilation GO:0042994 cytoplasmic sequestering of transcription factor GO:0055114 oxidation-reduction process GO:2001141 regulation of RNA biosynthetic process GO:0003714 transcription corepressor activity GO:0004602 glutathione peroxidase activity GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0051219 phosphoprotein binding GO:0005737 cytoplasm GO:0005829 cytosol GO:0004602 glutathione peroxidase activity
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length354
FASTA sequence>sp|P23202|URE2_YEAST Transcriptional regulator URE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URE2 PE=1 SV=1 MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
Structure Information
PDB ID1G6W 1G6Y 1JZR 1K0A 1K0B 1K0C 1K0D 1HQO
Quaternary structure
Function 1
Function descriptionfunctions in nitrogen catabolite repression binds to and inhibits GATA transcriptional activators GLN3 and GAT1, keeps them in the cytoplasm, prevents transcription of their target genes
References for functionCoschigano PW, Magasanik B. The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases. Mol Cell Biol. 1991 Feb. PMID: 1990286. Blinder D, Coschigano PW, Magasanik B. Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae. J Bacteriol. 1996 Aug. PMID: 8755910. Courchesne WE, Magasanik B. Regulation of nitrogen assimilation in Saccharomyces cerevisiae: roles of the URE2 and GLN3 genes. J Bacteriol. 1988 Feb. PMID: 2892826.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionglutathione peroxidase, enzyme also thiol:disulfide oxidoreductase 2 glutathione + H2O2 => glutathione disulfide + 2 H2O
References for functionBai M, Zhou JM, Perrett S. The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms. J Biol Chem. 2004 Nov 26. PMID: 15371425
E.C. number1.8.4.-
Location of functional site(s)
Cellular location of functioncytoplasm
Comments