Protein Information

General Information
MoonProt ID139
First appeared in release1.0
Name(s)Clf1p pre-mRNA splicing factor Pre-mRNA-splicing factor CLF1 Crooked neck-like factor 1 PRP19-associated complex protein 77 Synthetic lethal with CDC40 protein 3 Gene Name: CLF1
UniProt IDQ12309 (CLF1_YEAST), Reviewed
GO termsGO:0000354 cis assembly of pre-catalytic spliceosome GO:0006270 DNA replication initiation GO:0006270 DNA replication initiation GO:0006396 RNA processing GO:0006397 mRNA processing GO:0007049 cell cycle GO:0008380 RNA splicing GO:0003682 chromatin binding GO:0003688 DNA replication origin binding GO:0005515 protein binding contributes to GO:0000384 first spliceosomal transesterification activity contributes_to GO:0000386 second spliceosomal transesterification activity GO:0000785 chromatin GO:0000974 Prp19 complex GO:0005622 intracellular GO:0005634 nucleus GO:0005681 spliceosomal complex GO:0071004 U2-type prespliceosome GO:0071006 U2-type catalytic step 1 spliceosome GO:0071007 U2-type catalytic step 2 spliceosome GO:0071008 U2-type post-mRNA release spliceosomal complex GO:0003677 DNA binding GO:0006260 DNA replication
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length687
FASTA sequence>sp|Q12309|CLF1_YEAST Pre-mRNA-splicing factor CLF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLF1 PE=1 SV=1 MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIFPDDIDDDKPKPSKFLELAKKWKQEQAL
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionClf1p pre-mRNA splicing factor involved in assembly of spliceosome
References for functionRUSSELL, CAROLINE S., et al. "Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae." Rna 6.11 (2000): 1565-1572.
E.C. number
Location of functional site(s)
Cellular location of function
Comments
Function 2
Function descriptionInitiation of DNA replication binds to origin of replication complex
References for functionZhu W, Rainville IR, Ding M, Bolus M, Heintz NH, Pederson DS. Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae. Genetics. 2002 Apr. PMID: 11973290
E.C. numberN/A
Location of functional site(s)
Cellular location of function
Comments