Protein Information

General Information
MoonProt ID14
First appeared in release1.0
Name(s)alcohol acetaldehyde dehydrogenase (lmo1634) ADH ACDH Listeria adhesion protein LAP Gene Name = aad
UniProt IDQ6Q3I2 (Q6Q3I2_LISMN), Unreviewed
GO termsGO:0006066 alcohol metabolic process GO:0008152 metabolic process GO:0015976 carbon utilization GO:0055114 oxidation-reduction process GO:0004022 alcohol dehydrogenase (NAD) activity GO:0008774 acetaldehyde dehydrogenase (acetylating) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0046872 metal ion binding GO: 0098631 cell adhesion mediator activity GO: 0005515 protein binding
Organisms for which functions have been demonstratedListeria monocytogenes
Sequence length866
FASTA sequence>gi|45549367|gb|AAS67616.1| alcohol acetaldehyde dehydrogenase [Listeria monocytogenes] MAIKENAAQEVLEVQKVIDRLADNGQKALKAFESYNQEQVDNIVHAMALAGLDQHMPLAKLAVEETGRGLYEDKCIKNIFATEYIWNNIKNNKTVGVINEDVQTGVIEIAEPVGVVAGVTPVTNPTSTTLFKAIIAIKTRNPIIFAFHPSAQRCSSAAAKVVYDAAIAAGAPEHCIQWVEKPSLEATKQLMNHDKVALVLATGGAGMVKSAYSTGKPALGVGPGNVPAYIDKTAKIKRSVNDIILSKSFDQGMICASEQAVIVDKEVAKEVKAEMEANKCYFVKGAEFKKLESYVINPEKGTLNPDVVGKSPAWIANQAGFKVPEDTKILVAEIKGVGDKYPLSHEKLSPVLAFIEAANQAEAFDRCEEMLVYGGLGHSAVIHSTDKEVQKAFGIRMKACRIIVNAPSAQGGIGDIYNGFIPSLTLGCGSYGKNSVSQNVSATNLLNVKRIADRRNNMQWFKLPPKIFFEKYSTQYLQKMEGVERVFIVTDPGMGSFKYVDVVIEHLKKRGNDVAYQVFADVEPDPSDVTVYKGAELMKDFKPDTIIALGGGSAMDAAKGMWLFYEHPEASFFGLKQKFLDIRKRTFKYPKLGGKAKFVAIPTTSGTGSEVTPFAVITDKENNIKYPLADYELTPDVAIVDAQYVTTVPAHITADTGMDVLTHAIESYVSVMASDYTRGLSIRAIELVFENLRESVLTGDPDAREKMHNASALAGMAFANAFLGINHSLAHKIGPEFHIPHGRANAILMPHVIRYNALKPKKHALFPRYESFRADEDYARISRIIGFPAATTEEGVKSLVDEIIKLGKDVGIDMSLKGQNVAKKDLDAVVDTLADRAFMDQCTTANPKQPLVSELKEIYLEAYKGV
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionAn enzyme: The N-terminus contains acetaldehyde dehydrogenase (ALDH) and the Cterminus an alcohol dehydrogenase (ADH)
References for functionJagadeesan B, Koo OK, Kim KP, Burkholder KM, Mishra KK, Aroonnual A, Bhunia AK. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species. Microbiology. 2010 Sep;156:2782-2795 PMID: 20507888
E.C. numberEC=1.1.1.1 EC=1.2.1.10
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionAdhesin, binds Hsp60 on surface of host cells
References for functionJagadeesan B, Koo OK, Kim KP, Burkholder KM, Mishra KK, Aroonnual A, Bhunia AK. LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species. Microbiology. 2010 Sep;156:2782-2795 PMID: 20507888
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Commentsbinds Hsp60 on surface of host cells reference: Wampler JL, Kim KP, Jaradat Z, Bhunia AK.Heat shock protein 60 acts as a receptor for the Listeria adhesion protein in Caco-2 cells. Infect Immun. 2004 Feb;72(2):931-6. PMID: 14742538