Protein Information

General Information
MoonProt ID140
First appeared in release1.0
Name(s)Thymidine phosphorylase thymidine:phosphate deoxy-alpha-D-ribosyltransferase TP Gliostatin Platelet-derived endothelial cell growth factor PDGF PD-ECGF TdRPase Gene Name: TYMP
UniProt IDP19971 (TYPH_HUMAN) Reviewed
GO termsGO:0000002 mitochondrial genome maintenance GO:0001525 angiogenesis GO:0006206 pyrimidine nucleobase metabolic process GO:0006213 pyrimidine nucleoside metabolic process GO:0006220 pyrimidine nucleotide metabolic process GO:0006260 DNA replication GO:0006935 chemotaxis GO:0007275 multicellular organismal development GO:0008152 metabolic process GO:0030154 cell differentiation GO:0043097 pyrimidine nucleoside salvage GO:0044281 small molecule metabolic process GO:0046135 pyrimidine nucleoside catabolic process GO:0055086 nucleobase-containing small molecule metabolic process GO:0004645 phosphorylase activity GO:0005161 platelet-derived growth factor receptor binding GO:0008083 growth factor activity GO:0009032 thymidine phosphorylase activity GO:0016154 pyrimidine-nucleoside phosphorylase activity GO:0016740 transferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:0016763 transferase activity, transferring pentosyl groups GO:0005829 cytosol GO:0008083 growth factor activity
Organisms for which functions have been demonstratedHomo sapiens
Sequence length482
FASTA sequence>sp|P19971|TYPH_HUMAN Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2 MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPAEGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
Structure Information
PDB ID2WK5 2WK6 2J0F !UOU
Quaternary structure
Function 1
Function descriptionThymidine phosphorylase thymidine + phosphate <=> thymine + 2-deoxy-alpha-D-ribose 1-phosphate Pyrimidine metabolism, dTMP biosynthesis in salvage pathway
References for functionFonzo, Alessio Di, et al. "POLG mutations in sporadic mitochondrial disorders with multiple mtDNA deletions." Human mutation 22.6 (2003): 498-499.
E.C. number2.4.2.4
Location of functional site(s)Binding site:217,116,202,221
Cellular location of function
Comments
Function 2
Function descriptionPlatelet-derived endothelial cell growth factor
References for functionFurukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K, Ishizawa M, Yamada Y. Angiogenic factor. Nature. 1992 Apr 23. PMID: 1570012
E.C. numberN/A
Location of functional site(s)
Cellular location of functionextracellular, secreted
Comments