Protein Information

General Information
MoonProt ID144
First appeared in release1.0
Name(s)galactokinase Galactose kinase Gene Name: GAL1
UniProt IDP09608
GO termsGO:0005975 carbohydrate metabolic process GO:0006012 galactose metabolic process GO:0008152 metabolic process GO:0016310 phosphorylation GO:0046835 carbohydrate phosphorylation GO:0000166 nucleotide binding GO:0004335 galactokinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0005737 cytoplasm GO:0003677 DNA binding GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedKluyveromyces lactis
Sequence length503
FASTA sequence>sp|P09608|GAL1_KLULA Galactokinase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=GAL1 PE=2 SV=2 MSVPIVPTDFAHAPKLEQLKNEFVECYDTDDSRKFFITRSPGRVNLIGEHIDYCQFSVLPMAIENDLMLACRLTSESENPSITLTNHDSNFAQRKFDLPLDGSLIEIDPSVSDWSNYFKCGLLVAQQFLQEKYNFKGPVHGMEIYVKGDIPSGGGLSSSAAFICAVSLAIIYSNVPAGTPILKDELTKTTAVAEHHVGVNNGGMDQAASICGIEGHALYVEFKPELKATPFKFPEDLPISFLIANTLVVSNKAETGPVNYNLRVVEVTVAANVLAQKFGVTLQTEGNLGKGTLRNFMDSYYTKYDKSCRKPWDGEIQTGIERLNKMLQLVEETLDPNGYTLDHAVELCGCESISQFTELYLTNFPVRFQRLKLFQRAKHVYSEALRVLKALQLFQKGESNFFEEFGALMNESQESCDKLYECSCPETDSICEIALKNGSFGSRLTGAGWGGCTVHLCSTDTVDSVKSALTEQYYNLRFPELTAEELEDAIIISKPSLGSVLYE
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptiongalactokinase ATP + galactose => ADP + galactose 1-phosphate. Carbohydrate metabolism; galactose metabolism
References for functionMeyer, Jutta, A. Walker-Jonah, and C. P. Hollenberg. "Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae." Molecular and cellular biology 11.11 (1991): 5454-5461.
E.C. number2.7.1.6
Location of functional site(s)Active site:205 Nucleotide binding site:150-160 Other functional site:43
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontranscriptional activator of GAL genes
References for functionGalactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Meyer J., Walker-Jonah A., Hollenberg C.P. Mol. Cell. Biol. 11:5454-5461(1991). PMID: 1922058
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments