Protein Information

General Information
MoonProt ID148
First appeared in release1.0
Name(s)tyrosyl tRNA synthetase Tyrosine-tRNA ligase, mitochondrial TyrRS Gene Name: cyt-18
UniProt IDP12063 (SYYM_NEUCR), Reviewed
GO termsGO:0006397 mRNA processing GO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006437 tyrosyl-tRNA aminoacylation GO:0000166 nucleotide binding GO:0003723 RNA binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004831 tyrosine-tRNA ligase activity GO:0005524 ATP binding GO:0016874 ligase activity GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005759 mitochondrial matrix GO:0034337 RNA folding
Organisms for which functions have been demonstratedNeurospora crassa
Sequence length669
FASTA sequence>sp|P12063|SYYM_NEUCR Tyrosine--tRNA ligase, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cyt-18 PE=1 SV=2 MLLRTKALIRSGGSIAKYAAANPSCFILQRRGLRREFGPKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIAELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGSTAKIGDPTGRLKSRDHLSSSDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNNNHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPIMQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKYVTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYFVRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTLVHGKQEASAAEDQHRMMYTGQMTIPQVSRAKDAATGGDQYKTISDQPVTLNNAPRIDMILPESLIMGKSIGRILYAAGLASSTTEGHKLAAAQGCYVGGAHRAGGENVTMNPDLISFMPVKLWFPGETQRYLINGNLLILRKGKHNVRVIQMVSDVEYAASGQTYPGQSFTGAVRKLNEIMKNLKEKKLTPEEAKNAVNELQKSSQEKQQGQQIIFPEEKSRQKKDMETKLKQEMIASVKTIDGMMDEKPSVRGDGVKKQTQDDRDPYKW
Structure Information
PDB ID1Y42 2RKJ
Quaternary structure
Function 1
Function descriptiontyrosyl tRNA synthetase, enzyme attaches tyrosine to tRNA(Tyr) ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)
References for functionAkins, Robert A., and Alan M. Lambowitz. "A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof." Cell 50.3 (1987): 331-345.
E.C. number6.1.1.1
Location of functional site(s)Binding site:273,251,327,254,247,99,143,103
Cellular location of functionmitochondrion
Comments
Function 2
Function descriptionpromotes folding of group 1 introns
References for functionCaprara MG, Mohr G, Lambowitz AM. A tyrosyl-tRNA synthetase protein induces tertiary folding of the group I intron catalytic core. J Mol Biol. 1996 Apr 5. PMID: 8648621
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrion
Comments