Protein Information

General Information
MoonProt ID15
First appeared in release1.0
Name(s)alcohol dehydrogenase (EhADH2) ADH ACDH Aldehyde-alcohol dehydrogenase 2 Gene name = ADH2 Has two enzyme domains Alcohol dehydrogenase Acetaldehyde dehydrogenase
UniProt IDQ24803 (ADH2_ENTHI), Reviewed
GO termsGO:0006066 alcohol metabolic process GO:0008152 metabolic process GO:0015976 carbon utilization GO:0055114 oxidation-reduction process GO:0003824 catalytic activity GO:0004022 alcohol dehydrogenase (NAD) activity GO:0008774 acetaldehyde dehydrogenase (acetylating) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0046872 metal ion binding GO: 0098631 cell adhesion mediator activity GO: 0005515 protein binding
Organisms for which functions have been demonstratedEnteamoeba histolytica
Sequence length870
FASTA sequence>gi|2492737|sp|Q24803.1|ADH2_ENTHI RecName: Full=Aldehyde-alcohol dehydrogenase 2; Includes: RecName: Full=Alcohol dehydrogenase; Short=ADH; Includes: RecName: Full=Acetaldehyde dehydrogenase; Short=ACDH MSTQQTMTVDEHINQLVRKAQVALKEYLKPEYTQEKIDYIVKKASVAALDQHCALAAAAVEETGRGIFEDKATKNIFACEHVTHEMRHAKTVGIINVDPLYGITEIAEPVGVVCGVTPVTNPTSTAIFKSLISIKTRNPIVFSFHPSALKCSIMAAKIVRDAAIAAGAPENCIQWIEFGGIEASNKLMNHPGVATILATGGNAMVKAAYSSGKPALGVGAGNVPTYIEKTCNIKQAANDVVMSKSFDNGMICASEQAAIIDKEIYDQVVEEMKTLGAYFINEEEKAKLEKFMFGVNAYSADVNNARLNPKCPGMSPQWFAEQVGIKVPEDCNIICAVCKEVGPNEPLTREKLSPVLAILKAENTQDGIDKAEAMVEFNGRGHSAAIHSNDKAVVEKYALTMKACRILHNTPSSQGGIGSIYNYIWPSFTLGCGSYGGNSVSANVTYHNLLNIKRLADRRNNLQWFRVPPKIFFEPHSIRYLAELKELSKIFIVSDRMMYKLGYVDRVMDVLKRRSNEVEIEIFIDVEPDPSIQTVQKGLAVMNTFGPDNIIAIGGGSAMDAAKIMWLLYEHPEADFFAMKQKFIDLRKRAFKFPTMGKKARLICIPTTSGTGSEVTPFAVISDHETGKKYPLADYSLTPSVAIVDPMFTMSLPKRAIADTGLDVLVHATEAYVSVMANEYTDGLAREAVKLVFENLLKSYNGDLEAREKMHNAATIAGMAFASAFLGMDHSMAHKVGAAFHLPHGRCVAVLLPHVIRYNGQKPRKLAMWPKYNFYKADQRYMELAQMVGLKCNTPAEGVEAFAKACEELMKATETITGFKKANIDEAAWMSKVPEMALLAFEDQCSPANPRVPMVKDMEKILKAAYYPIA
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionalcohol dehydrogenase (EhADH2), enzyme Including the following 2 domains: Alcohol dehydrogenase and Acetaldehyde dehydrogenase An alcohol + NAD+ => an aldehyde or ketone + NADH Acetaldehyde + CoA + NAD+ => acetyl-CoA + NADH. demonstrated that it has both ADH and acetaldehyde dehydrogenase activity.
References for functionYang W, Li E, Kairong T, Stanley SL Jr. Entamoeba histolytica has an alcohol dehydrogenase homologous to the multifunctional adhE gene product of Escherichia coli. Mol Biochem Parasitol. 1994 Apr;64(2):253-60. PMID: 7935603.
E.C. numberHas two enzyme domains: EC=1.1.1.1 and EC=1.2.1.10
Location of functional site(s)Active site:252 Nucleotide binding site:431-436
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds fibronectin, laminin, and type II collagen
References for functionYang W, Li E, Kairong T, Stanley SL Jr. Entamoeba histolytica has an alcohol dehydrogenase homologous to the multifunctional adhE gene product of Escherichia coli. Mol Biochem Parasitol. 1994 Apr;64(2):253-60. PMID: 7935603.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments