Protein Information

General Information
MoonProt ID150
First appeared in release1.0
Name(s)aconitase iron-responsive element binding protein Cytoplasmic aconitate hydratase Citrate hydro-lyase Iron-responsive element-binding protein 1 IRE-BP 1 Gene Name:ACO1
UniProt IDQ0VCU1 (ACOC_BOVIN) Reviewed
GO termsGO:0006099 tricarboxylic acid cycle GO:0006101 citrate metabolic process GO:0008152 metabolic process GO:0010040 response to iron(II) ion GO:0003723 RNA binding GO:0003994 aconitate hydratase activity GO:0016829 lyase activity GO:0030350 iron-responsive element binding GO:0046872 metal ion binding GO:0051536 iron-sulfur cluster binding GO:0051539 4 iron, 4 sulfur cluster binding GO:0005737 cytoplasm GO:0003729 mRNA binding GO:0006417 regulation of translation
Organisms for which functions have been demonstratedBos taurus (bovine)
Sequence length889
FASTA sequence>sp|Q0VCU1|ACOC_BOVIN Cytoplasmic aconitate hydratase OS=Bos taurus GN=ACO1 PE=2 SV=1 MSNPFAHLVEPLDPAQPGKKFFNLNKLEDSRYGSLPFSIRVLLEAAIRNCDQFLVKKNDVENILNWKVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPICPADLVIDHSIQVDFNRRADSLKKNQDLEFERNKERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYRLVGNPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIKYLVQTGRDKEKVKHIKQYLQAVGMFRDFSDSSQDPDFAQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNNSKFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEAVVEAIVQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALAAPSDKLYCWNPKSTYIKSPPFFEDLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGSGSSRDWAAKGPFLLGIRAVLAESYERIHRSNLVGMGVIPLEYLPGENADTLGLTGRERYTISIPETLKPRMKVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMTK
Structure Information
PDB ID2B3X 2B3Y
Quaternary structure
Function 1
Function descriptionaconitase, enzyme 4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate Citric acid cycle
References for functionEchard, G., et al. "Present status of the ovine gene map (Ovis aries); comparison with the bovine map (Bos taurus)." Mammalian Genome 5.6 (1994): 324-332.
E.C. number4.2.1.3
Location of functional site(s)Binding site:536,86,541,699 Metal binding site:437,503,506
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioniron responsive element binding protein when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use
References for functionKennedy MC, MendeMueller L, Blondin GA, Beinert H. Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc Natl Acad Sci U S A. 1992 Dec 15. PMID: 1334546
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments