Protein Information

General Information
MoonProt ID152
First appeared in release1.0
Name(s)dihydroxyacetone kinase glycerone kinase
UniProt IDQ8XDH4 (Q8XDH4_ECO57), Unreviewed
GO termsGO:0006071 glycerol metabolic process GO:0016310 phosphorylation GO:0051156 glucose 6-phosphate metabolic process GO:0004340 glucokinase activity GO:0004371 glycerone kinase activity GO:0016301 kinase activity GO:0016740 transferase activity GO:0008134 transcription factor binding GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedEscherichia coli
Sequence length366
FASTA sequence>gi|13361170|dbj|BAB35128.1| dihydroxyacetone kinase [Escherichia coli O157:H7 str. Sakai] MPYRNCWSKIMKKLINDVQDVLDEQLAGLAKAHPSLTLHQDPVYVTRADAPVAGKVALLSGGGSGHEPMHCGYIGQGMLSGACPGEIFTSPTPDKIFECAMQVDGGEGVLLIIKNYTGDILNFETATELLHDSGVKVTTVVIDDDVAVKDSLYTAGRRGVANTVLIEKLVGAAAERGDSLDACAELGRKLNNQGHSIGIALGACTVPAAGKPSFTLADNEMEFGVGIHGEPGIDRRPFSSLDQTVDEMFDTLLENGSYHRTLRFWDYQQGSWQEEPQTKQPLQSGDGVIALVNNLGATPLSELYGVYNRLTTRCQQAGLTIERNLIGAYCTSLDMTGFSITLLKVDDETLALWDAPVHTPALNWGK
Structure Information
PDB ID1OI2 1OI3 1UOD 1UOE 4LRX 3PNK 3PNL 4LRY 3PNO 3PNQ 3PNM
Quaternary structure
Function 1
Function descriptiondihydroxyacetone kinase, enzyme ATP + glycerone <=> ADP + glycerone phosphate (glycerone also called dihydroxyacetone)
References for functionGutknecht, Regula, et al. "The dihydroxyacetone kinase of Escherichia coli utilizes a phosphoprotein instead of ATP as phosphoryl donor." The EMBO journal 20.10 (2001): 2480-2486.
E.C. number2.7.1.29
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioncontrols gene expression by binding to transcription factor DhaR, a trigger enzyme
References for functionB?chler C, Schneider P, B?hler P, Lustig A, Erni B. Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR. EMBO J. 2005 Jan 26. PMID: 15616579
E.C. numberN/A
Location of functional site(s)
Cellular location of functionbinding to DNA
Comments