Protein Information

General Information
MoonProt ID161
First appeared in release1.0
Name(s)Cyclic AMP-dependent transcription factor ATF-2 cAMP-dependent transcription factor ATF-2 Activating transcription factor 2 Cyclic AMP-responsive element-binding protein 2 CREB-2 cAMP-responsive element-binding protein 2 HB16 Histone acetyltransferase ATF2 cAMP response element-binding protein CRE-BP1 Gene Name:ATF2
UniProt IDP15336 (ATF2_HUMAN), Reviewed
GO termsGO:0002224 toll-like receptor signaling pathway GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002756 MyD88-independent toll-like receptor signaling pathway GO:0003151 outflow tract morphogenesis GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006970 response to osmotic stress GO:0006974 cellular response to DNA damage stimulus GO:0016573 histone acetylation GO:0031573 intra-S DNA damage checkpoint GO:0032915 positive regulation of transforming growth factor beta2 production GO:0034134 toll-like receptor 2 signaling pathway GO:0034138 toll-like receptor 3 signaling pathway GO:0034142 toll-like receptor 4 signaling pathway GO:0034146 toll-like receptor 5 signaling pathway GO:0034162 toll-like receptor 9 signaling pathway GO:0034166 toll-like receptor 10 signaling pathway GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway GO:0045087 innate immune response GO:0045444 fat cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051403 stress-activated MAPK cascade GO:0060612 adipose tissue development GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001076 RNA polymerase II transcription factor binding transcription factor activity GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001102 RNA polymerase II activating transcription factor binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 sequence-specific DNA binding transcription factor activity GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0005515 protein binding GO:0008140 cAMP response element binding protein binding GO:0016740 transferase activity GO:0019901 protein kinase binding GO:0035497 cAMP response element binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0016020 membrane GO:0035861 site of double-strand break GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length505
FASTA sequence>sp|P15336|ATF2_HUMAN Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens GN=ATF2 PE=1 SV=4 MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun
References for functionBhoumik, Anindita, et al. "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response." Molecular cell18.5 (2005): 577-587.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments
Function 2
Function descriptionrecruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-Jun
References for functionBhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell. 2005 May 27. PMID: 15916964
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments