Protein Information

General Information
MoonProt ID171
First appeared in release1.0
Name(s)60S ribosomal protein L13a 23 kDa highly basic protein Gene Name: RPL13A
UniProt IDP40429 (RL13A_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006417 regulation of translation GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0017148 negative regulation of translation GO:0019058 viral life cycle GO:0019083 viral transcription GO:0044267 cellular protein metabolic process GO:0071346 cellular response to interferon-gamma GO:1901194 negative regulation of formation of translation preinitiation complex GO:0003735 structural constituent of ribosome GO:0044822 poly(A) RNA binding GO:0005737 cytoplasm GO:0005829 cytosol GO:0005840 ribosome GO:0015934 large ribosomal subunit GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0097452 GAIT complex GO:0006412 translation
Organisms for which functions have been demonstratedHomo sapien
Sequence length203
FASTA sequence>sp|P40429|RL13A_HUMAN 60S ribosomal protein L13a OS=Homo sapiens GN=RPL13A PE=1 SV=2 MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV
Structure Information
PDB ID3J3B
Quaternary structure
Function 1
Function descriptionribosome protein, part of 60S subunit of ribosome
References for functionChaudhuri, Sujan, et al. "Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation." Rna 13.12 (2007): 2224-2237.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasem, part of ribosome
Comments
Function 2
Function descriptiontranslation inhibition Component of the GAIT complex (gamma interferon-activated inhibitor of translation)
References for functionMazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell. 2003 Oct 17. PMID: 14567916
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments