Protein Information

General Information
MoonProt ID173
First appeared in release1.0
Name(s)Glyceraldehyde-3-phosphate dehydrogenase GAPDH Peptidyl-cysteine S-nitrosylase GAPDH Gene Name: GAPDH
UniProt IDP04406 (G3P_HUMAN), Reviewed
GO termsGO:0000226 microtubule cytoskeleton organization GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006096 glycolysis GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0017148 negative regulation of translation GO:0035606 peptidyl-cysteine S-trans-nitrosylation GO:0044281 small molecule metabolic process GO:0050821 protein stabilization GO:0051402 neuron apoptotic process GO:0055114 oxidation-reduction process GO:0071346 cellular response to interferon-gamma GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0005515 protein binding GO:0008017 microtubule binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 transferase activity GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0042802 identical protein binding GO:0050661 NADP binding GO:0051287 NAD binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0005811 lipid particle GO:0005829 cytosol GO:0005856 cytoskeleton GO:0005886 plasma membrane GO:0015630 microtubule cytoskeleton GO:0016020 membrane GO:0030529 ribonucleoprotein complex GO:0048471 perinuclear region of cytoplasm GO:0070062 extracellular vesicular exosome GO:0097452 GAIT complex GO:0006412 translation
Organisms for which functions have been demonstratedHomo sapiens
Sequence length335
FASTA sequence>sp|P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3 MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionglyceraldehyde-3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bis-phosphogycerate + NADH Carbohydrate degradation, glycolysis
References for function
E.C. number1.2.1.12
Location of functional site(s)Active site:152 Binding site:182,316,122,234,35,80 Nucleotide binding site:13-14 Other functional site:179
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontranslation inhibition part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation that silences ceruloplasmin mRNA translation
References for functionSampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL. Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. Cell. 2004 Oct 15. PMID: 15479637
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments