Protein Information

General Information
MoonProt ID177
First appeared in release1.0
Name(s)60S ribosomal protein L10 Laminin receptor homolog Protein QM Tumor suppressor QM Gene Name: RPL10
UniProt IDP27635 (RL10_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0044267 cellular protein metabolic process GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0044822 poly(A) RNA binding GO:0005622 intracellular GO:0005783 endoplasmic reticulum GO:0005829 cytosol GO:0005840 ribosome GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0008134 transcription factor binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length214
FASTA sequence>sp|P27635|RL10_HUMAN 60S ribosomal protein L10 OS=Homo sapiens GN=RPL10 PE=1 SV=4 MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
Structure Information
PDB ID2ZKR, 3J3B
Quaternary structure
Function 1
Function descriptionComponent of the large subunit (60S) of the ribosome
References for functionRamirez, Celia, et al. "Structure and evolution of the L11, L1, L10, and L12 equivalent ribosomal proteins in eubacteria, archaebacteria, and eucaryotes." Canadian journal of microbiology 35.1 (1989): 234-244.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptionnegative regulator of c-Jun in transcription
References for functionImafuku I, Masaki T, Waragai M, Takeuchi S, Kawabata M, Hirai S, Ohno S, Nee LE, Lippa CF, Kanazawa I, Imagawa M, Okazawa H. Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J Cell Biol. 1999 Oct 4. PMID: 10508860
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments