Protein Information

General Information
MoonProt ID184
First appeared in release1.0
Name(s)60S ribosomal protein L11 Gene Name: Rpl11
UniProt IDQ9CXW4 (RL11_MOUSE), Reviewed
GO termsGO:0006412 translation GO:0034504 protein localization to nucleus GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0019843 rRNA binding GO:0005622 intracellular GO:0005634 nucleus GO:0005730 nucleolus GO:0005840 ribosome GO:0030529 ribonucleoprotein complex GO:0005515 protein binding GO:ubiquitin protein ligase binding
Organisms for which functions have been demonstratedMus musculus
Sequence length178
FASTA sequence>sp|Q9CXW4|RL11_MOUSE 60S ribosomal protein L11 OS=Mus musculus GN=Rpl11 PE=1 SV=4 MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
Structure Information
PDB ID2ZKR, 3J3B
Quaternary structure
Function 1
Function descriptionribosomal protein, part of 60S subunit
References for functionMorgado-Palacin, Lucia, Susana Llanos, and Manuel Serrano. "Ribosomal stress induces L11-and p53-dependent apoptosis in mouse pluripotent stem cells." Cell Cycle 11.3 (2012): 503-510.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptionBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein
References for functionLohrum MA, Ludwig RL, Kubbutat MH, Hanlon M, Vousden KH. Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell. 2003 Jun. PMID: 12842086
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments