Protein Information

General Information
MoonProt ID185
First appeared in release1.0
Name(s)60S ribosomal protein L11 CLL-associated antigen KW-12 Gene Name:Rpl11
UniProt IDP62913 (RL11_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006364 rRNA processing GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006605 protein targeting GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0034504 protein localization to nucleus GO:0042273 ribosomal large subunit biogenesis GO:0044267 cellular protein metabolic process GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0019843 rRNA binding GO:0044822 poly(A) RNA binding GO:0005622 intracellular GO:0005634 nucleus GO:0005730 nucleolus GO:0005829 cytosol GO:0005840 ribosome GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0070062 extracellular vesicular exosome GO:0005515 protein binding GO:ubiquitin protein ligase binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length178
FASTA sequence>sp|P62913|RL11_HUMAN 60S ribosomal protein L11 OS=Homo sapiens GN=RPL11 PE=1 SV=2 MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
Structure Information
PDB ID2ZKR, 3J3B
Quaternary structure
Function 1
Function descriptionribosomal protein, part of 60S subunit
References for functionMishin, V. P., et al. "Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11." Bioorganicheskaia khimiia 21.2 (1995): 158-160.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptionBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein
References for functionZhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003 Dec. PMID: 14612427
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments