Protein Information

General Information
MoonProt ID186
First appeared in release1.0
Name(s)60S ribosomal protein L5 Gene Name:RPL5
UniProt IDP46777 (RL5_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006364 rRNA processing GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0042273 ribosomal large subunit biogenesis GO:0044267 cellular protein metabolic process GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0008097 5S rRNA binding GO:0019843 rRNA binding GO:0044822 poly(A) RNA binding GO:0005622 intracellular GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005840 ribosome GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0070062 extracellular vesicular exosome GO:0005515 protein binding GO:ubiquitin protein ligase binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length297
FASTA sequence>sp|P46777|RL5_HUMAN 60S ribosomal protein L5 OS=Homo sapiens GN=RPL5 PE=1 SV=3 MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Structure Information
PDB ID3J3B, 2ZKR
Quaternary structure
Function 1
Function descriptionribosomal protein, part of the 60S subunit
References for functionChan, YUEN-LING, et al. "The primary structure of rat ribosomal protein L5. A comparison of the sequence of amino acids in the proteins that interact with 5 S rRNA." Journal of Biological Chemistry 262.26 (1987): 12879-12886.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of the ribosome
Comments
Function 2
Function descriptionBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor protein
References for functionHorn HF, Vousden KH. Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. Oncogene. 2008 Oct 2. PMID: 18560357
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments