Protein Information

General Information
MoonProt ID187
First appeared in release1.0
Name(s)40S ribosomal protein S7 Gene Name:RPS7
UniProt IDP62081 (RS7_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006364 rRNA processing GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0042274 ribosomal small subunit biogenesis GO:0044267 cellular protein metabolic process GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0044822 poly(A) RNA binding GO:0005622 intracellular GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005815 microtubule organizing center GO:0005829 cytosol GO:0005840 ribosome GO:0005856 cytoskeleton GO:0022627 cytosolic small ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0030686 90S preribosome GO:0032040 small-subunit processome GO:0005515 protein binding GO:ubiquitin protein ligase binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length194
FASTA sequence>sp|P62081|RS7_HUMAN 40S ribosomal protein S7 OS=Homo sapiens GN=RPS7 PE=1 SV=1 MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
Structure Information
PDB ID3J3A, 4KZX, 4KZY, 4KZZ
Quaternary structure
Function 1
Function descriptionribosomal protein, part of 40S subunit
References for functionAnnilo, Tarmo, et al. "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25." Gene 165.2 (1995): 297-302.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptionBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor protein
References for functionChen D, Zhang Z, Li M, Wang W, Li Y, Rayburn ER, Hill DL, Wang H, Zhang R. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007 Aug 2. PMID: 17310983
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments