Protein Information

General Information
MoonProt ID188
First appeared in release1.0
Name(s)60S ribosomal protein L26 Gene Name:RPL26
UniProt IDP61254 (RL26_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006364 rRNA processing GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0042273 ribosomal large subunit biogenesis GO:0044267 cellular protein metabolic process GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0044822 poly(A) RNA binding GO:0005622 intracellular GO:0005829 cytosol GO:0005840 ribosome GO:0015934 large ribosomal subunit GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0070062 extracellular vesicular exosome GO:0006412 translation GO:0003729 mRNA binding GO:0003723 RNA binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length145
FASTA sequence>sp|P61254|RL26_HUMAN 60S ribosomal protein L26 OS=Homo sapiens GN=RPL26 PE=1 SV=1 MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE
Structure Information
PDB ID2ZKR, 3J3B
Quaternary structure
Function 1
Function descriptionribosomal protein, part of 60S subunit
References for functionZaman, G. J. "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6." Nucleic acids research 21.7 (1993): 1673.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptionregulates (increases) translation of p53 tumor suppressor protein after DNA damage, leading to cell cycle arrest and apoptosis binds 5' UTR of p53 mRNA
References for functionTakagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005 Oct 7. PMID: 16213212
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments