Protein Information

General Information
MoonProt ID189
First appeared in release1.0
Name(s)Nucleolin Protein C23 Gene Name:NCL
UniProt IDP19338 (NUCL_HUMAN), Reviewed
GO termsGO:0001525 angiogenesis GO:0000166 nucleotide binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003723 RNA binding GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0042162 telomeric DNA binding GO:0042802 identical protein binding GO:0044822 poly(A) RNA binding GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005938 cell cortex GO:0030529 ribonucleoprotein complex GO:0070062 extracellular vesicular exosome GO:0003723 RNA binding GO:0004612 translation GO:0003729 mRNA binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length710
FASTA sequence>sp|P19338|NUCL_HUMAN Nucleolin OS=Homo sapiens GN=NCL PE=1 SV=3 MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionsynthesis and maturation of ribosomes
References for functionSrivastava, Meera, et al. "Cloning and sequencing of the human nucleolin cDNA." FEBS letters 250.1 (1989): 99-105.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus, nucleolus
Comments
Function 2
Function descriptionregulates (decreases) translation of p53 tumor suppressor protein binds 5' UTR of p53 mRNA
References for functionTakagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005 Oct 7. PMID: 16213212
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments