Protein Information

General Information
MoonProt ID190
First appeared in release1.0
Name(s)60S ribosomal protein L23 60S ribosomal protein L17 Gene Name:RPL23
UniProt IDP62829 (RL23_HUMAN), Reviewed
GO termsGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006610 ribosomal protein import into nucleus GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0044267 cellular protein metabolic process GO:0003735 structural constituent of ribosome GO:0005515 protein binding GO:0044822 poly(A) RNA binding GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005840 ribosome GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0070062 extracellular vesicular exosome GO:0005515 protein binding GO:003165 ubiquitin protein ligase binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length140
FASTA sequence>sp|P62829|RL23_HUMAN 60S ribosomal protein L23 OS=Homo sapiens GN=RPL23 PE=1 SV=1 MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA
Structure Information
PDB ID2ZKR, 3J3B
Quaternary structure
Function 1
Function descriptionribosomal protein, part of 60S subunit
References for functionYoshihama, Maki, et al. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Genome research 12.3 (2002): 379-390.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of ribosome
Comments
Function 2
Function descriptionBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein
References for functionDai MS, Zeng SX, Jin Y, Sun XX, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004 Sep. PMID: 15314173
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Third Function
Function descriptionbinds nucleophosmin and sequesters it in the nucleolus so that it can't bind to Miz1 (a transcriptional activator and repressor), so has a role in inhibiting cell-cycle arrest
References for functionWanzel M, Russ AC, KleineKohlbrecher D, Colombo E, Pelicci PG, Eilers M. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat Cell Biol. 2008 Sep. PMID: 19160485
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleolus
Comments