Protein Information

General Information
MoonProt ID194
First appeared in release1.0
Name(s)50S ribosomal protein L4 Gene Name:rplD
UniProt IDP60723 (RL4_ECOLI), Reviewed
GO termsGO:0006351 transcription, DNA-templated GO:0006353 DNA-templated transcription, termination GO:0006355 regulation of transcription, DNA-templated GO:0006412 translation GO:0006417 regulation of translation GO:0017148 negative regulation of translation GO:0046677 response to antibiotic GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding GO:0030371 translation repressor activity GO:0005840 ribosome GO:0022625 cytosolic large ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0003677 DNA binding GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedEscherichia coli
Sequence length201
FASTA sequence>sp|P60723|RL4_ECOLI 50S ribosomal protein L4 OS=Escherichia coli (strain K12) GN=rplD PE=1 SV=1 MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
Structure Information
PDB ID1P85 and many others
Quaternary structure
Function 1
Function descriptionribosomal protein, part of the 50S subunit
References for functionYates, John L., and Masayasu Nomura. "E. coli ribosomal protein L4 is a feedback regulatory protein." Cell 21.2 (1980): 517-522.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of the ribosome
Comments
Function 2
Function descriptiontranscriptional repressor causes premature termination of transcription within S10 operon
References for functionZengel JM, Lindahl L. A hairpin structure upstream of the terminator hairpin required for ribosomal protein L4-mediated attenuation control of the S10 operon of Escherichia coli. J Bacteriol. 1996 Apr. PMID: 8636042
E.C. numberN/A
Location of functional site(s)
Cellular location of functionbinding to DNA
Comments
Third Function
Function descriptionbinds to mRNA and regulates translation
References for functionZengel JM, Lindahl L. A hairpin structure upstream of the terminator hairpin required for ribosomal protein L4-mediated attenuation control of the S10 operon of Escherichia coli. J Bacteriol. 1996 Apr. PMID: 8636042
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments