Protein Information

General Information
MoonProt ID196
First appeared in release1.0
Name(s)D-fructose 1,6-bisphosphate aldolase/phosphatase Fructose-1,6-bisphosphatase Gene Name:fbp
UniProt IDF9VMT6 (F9VMT6_SULTO), Unreviewed
GO termsGO:0008152 metabolic process GO:0016311 dephosphorylation GO:0016787 hydrolase activity GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GO:0046872 metal ion binding GO:0004332 fructose-biphosphate aldolase activity
Organisms for which functions have been demonstratedSulfolobus tokodaii
Sequence length384
FASTA sequence>sp|F9VMT6|FBPAP_SULTO Fructose-1,6-bisphosphate aldolase/phosphatase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=fbp PE=1 SV=1 MKTTISVIKADIGSLAGHHIVHPDTMAAANKVLASAKEQGIILDYYITHVGDDLQLIMTHTRGELDTKVHETAWNAFKEAAKVAKDLGLYAAGQDLLSDSFSGNVRGLGPGVAEMEIEERASEPIAIFMADKTEPGAYNLPLYKMFADPFNTPGLVIDPTMHGGFKFEVLDVYQGEAVMLSAPQEIYDLLALIGTPARYVIRRVYRNEDNLLAAVVSIERLNLIAGKYVGKDDPVMIVRLQHGLPALGEALEAFAFPHLVPGWMRGSHYGPLMPVSQRDAKATRFDGPPRLLGLGFNVKNGRLVGPTDLFDDPAFDETRRLANIVADYMRRHGPFMPHRLEPTEMEYTTLPLILEKLKDRFKKESDVYKAKESIYAKEESQGHD
Structure Information
PDB ID1UMG, 2QUT,
Quaternary structure
Function 1
Function descriptionfructose-1,6-bisphosphatase, enzyme dephosphorylation of FBP to fructose-6-phosphate
References for functionFushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9. PMID: 21983966
E.C. number3.1.3.11
Location of functional site(s)Active site:231,11,228 Binding site:90,132,18,265,286,347 Metal binding site:233,94,131,53,18,52,11,231,232
Cellular location of functioncytoplasm
CommentsNote - both functions in same active site
Function 2
Function descriptionfructose-1,6-bisphosphate aldolase, enzyme reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBP
References for functionFushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9. PMID: 21983966
E.C. number4.1.2.13
Location of functional site(s)
Cellular location of functioncytoplasm
CommentsNote - both functions in same active site