Protein Information

General Information
MoonProt ID198
First appeared in release1.0
Name(s)DegQ Periplasmic pH-dependent serine endoprotease DegQ Protease Do Gene Name:degQ
UniProt IDP39099 (DEGQ_ECOLI), Reviewed
GO termsGO:0006508 proteolysis GO:0006950 response to stress GO:0051603 proteolysis involved in cellular protein catabolic process GO:0003824 catalytic activity GO:0004252 serine-type endopeptidase activity GO:0008233 peptidase activity GO:0008236 serine-type peptidase activity GO:0016787 hydrolase activity GO:0042597 periplasmic space GO:0071575 integral component of external side of plasma membrane GO:0061077 chaperone-mediated protein folding
Organisms for which functions have been demonstratedEscherichia coli
Sequence length455
FASTA sequence>sp|P39099|DEGQ_ECOLI Periplasmic pH-dependent serine endoprotease DegQ OS=Escherichia coli (strain K12) GN=degQ PE=1 SV=1 MKKQTQLLSALALSVGLTLSASFQAVASIPGQVADQAPLPSLAPMLEKVLPAVVSVRVEGTASQGQKIPEEFKKFFGDDLPDQPAQPFEGLGSGVIINASKGYVLTNNHVINQAQKISIQLNDGREFDAKLIGSDDQSDIALLQIQNPSKLTQIAIADSDKLRVGDFAVAVGNPFGLGQTATSGIVSALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSVGIGFAIPSNMARTLAQQLIDFGEIKRGLLGIKGTEMSADIAKAFNLDVQRGAFVSEVLPGSGSAKAGVKAGDIITSLNGKPLNSFAELRSRIATTEPGTKVKLGLLRNGKPLEVEVTLDTSTSSSASAEMITPALEGATLSDGQLKDGGKGIKIDEVVKGSPAAQAGLQKDDVIIGVNRDRVNSIAEMRKVLAAKPAIIALQIVRGNESIYLLMR
Structure Information
PDB ID4A8A, 4A8B, 4A8C, 4A9G, 3STJ
Quaternary structure
Function 1
Function descriptionpeptidase, enzyme
References for functionSawa J, Malet H, Krojer T, Canellas F, Ehrmann M, Clausen T. Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope. J Biol Chem. 2011 Sep 2. PMID: 21685389
E.C. number3.4.21.107
Location of functional site(s)Active site:214,139,109 Binding site:212,59,139,109
Cellular location of functionPeriplasm
Comments
Function 2
Function descriptionchaperone, aids in folding of proteins
References for functionMalet H, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, Saibil HR. Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ. Nat Struct Mol Biol. 2012 Jan 15. PMID: 22245966
E.C. numberN/A
Location of functional site(s)
Cellular location of functionPeriplasm
Comments