Protein Information

General Information
MoonProt ID199
First appeared in release1.0
Name(s)DNA replication factor Cdt1 Double parked homolog DUP Gene Name:CDT1
UniProt IDQ9H211 (CDT1_HUMAN), Reviewed
GO termsGO:0000076 DNA replication checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000278 mitotic cell cycle GO:0006260 DNA replication GO:0007049 cell cycle GO:0030174 regulation of DNA-dependent DNA replication initiation GO:0033262 regulation of nuclear cell cycle DNA replication GO:0003677 DNA binding GO:0005515 protein binding GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005829 cytosol GO:0000278 mitotic cell cycle GO:0043515 kinetochore binding GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length546
FASTA sequence>sp|Q9H211|CDT1_HUMAN DNA replication factor Cdt1 OS=Homo sapiens GN=CDT1 PE=1 SV=3 MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL
Structure Information
PDB ID2WVR
Quaternary structure
Function 1
Function descriptionhelps load proteins onto chromatin to create the pre-replication complex for initiating DNA replication
References for functionWohlschlegel, James A., et al. "Inhibition of eukaryotic DNA replication by geminin binding to Cdt1." Science 290.5500 (2000): 2309-2312.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments
Function 2
Function descriptionrole in mitosis localizes to kinetochores through binding to the Hec1 component of the Ndc80 complex
References for functionVarma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA, Nevis KR, DeLuca JG, Salmon ED, Cook JG. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat Cell Biol. 2012 May 13. PMID: 22581055
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, on kinetochores during mitosis
Comments