Protein Information

General Information
MoonProt ID2
First appeared in release1.0
Name(s)Transcription antitermination protein RfaH Gene Name:rfaH
UniProt IDP0AFW0 (RFAH_ECOLI), Reviewed
GO termsGO:0001124 transcription elongation from bacterial-type RNA polymerase promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0031564 transcription antitermination GO:0045727 positive regulation of translation GO:0001000 bacterial-type RNA polymerase core enzyme binding GO:0001073 DNA binding transcription antitermination factor activity GO:0003677 DNA binding GO:0005515 protein binding GO:0008494 translation activator activity GO:0003729 mRNA binding GO:0006417 regulation of translation
Organisms for which functions have been demonstratedEscherichia coli
Sequence length162
FASTA sequence>sp|P0AFW0|RFAH_ECOLI Transcription antitermination protein RfaH OS=Escherichia coli (strain K12) GN=rfaH PE=1 SV=1 MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL
Structure Information
PDB ID2OUG, 2LCL
Quaternary structure
Function 1
Function descriptionaids in transcription elongation of long RNA chains, reduces pausing and inhibits termination
References for functionPradel, E. L. I. Z. A. B. E. T. H., and CARL A. Schnaitman. "Effect of rfaH (sfrB) and temperature on expression of rfa genes of Escherichia coli K-12." Journal of bacteriology 173.20 (1991): 6428-6431.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionbound to DNA
Comments
Function 2
Function descriptiontranslational regulator
References for functionBurmann BM, Knauer SH, Sevostyanova A, Schweimer K, Mooney RA, Landick R, Artsimovitch I, R?sch P. An a helix to ? barrel domain switch transforms the transcription factor RfaH into a translation factor. Cell. 2012 Jul 20. PMID: 22817892
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments