Protein Information

General Information
MoonProt ID21
First appeared in release1.0
Name(s)DnaK Hsp70 molecular chaperone DnaK Chaperone protein DnaK Heat shock 70 kDa protein Heat shock protein 70 Gene Name: dnaK
UniProt IDA0A0H3L5C8
GO termsGO:0006457 protein folding GO:0006950 response to stress GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0016787 hydrolase activity GO:0051082 unfolded protein binding GO: 0005515 protein binding
Organisms for which functions have been demonstratedMycobacterium tuberculosis H37Rv (ATCC no. 27294)
Sequence length625
FASTA sequence>tr|A0A0H3L5C8|A0A0H3L5C8_MYCTE Chaperone protein DnaK OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) GN=dnaK PE=2 SV=1 MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionchaperone
References for functionKennaway, Christopher K., et al. "Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis." Journal of biological chemistry 280.39 (2005): 33419-33425.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding
References for functionXolalpa W, Vallecillo AJ, Lara M, MendozaHernandez G, Comini M, Spallek R, Singh M, Espitia C. Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis. Proteomics. 2007 Sep;7(18):3332-41. PMID: 17849409
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments