Protein Information

General Information
MoonProt ID210
First appeared in release1.0
Name(s)PTS system glucose-specific EIICB component EIICB-Glc EII-Glc Glucose permease IIC component PTS system glucose-specific EIIC component Glucose-specific phosphotransferase enzyme IIB component PTS system glucose-specific EIIB component Gene Name:ptsG
UniProt IDP69786 (PTGCB_ECOLI), Reviewed
GO termsGO:0006810 transport GO:0008643 carbohydrate transport GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0015758 glucose transport GO:0015992 proton transport GO:0016310 phosphorylation GO:0034219 carbohydrate transmembrane transport GO:0005351 sugar:hydrogen symporter activity GO:0005355 glucose transmembrane transporter activity GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0016301 kinase activity GO:0016740 transferase activity GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0005515 protein binding GO:0008134 transcription factor binding
Organisms for which functions have been demonstratedEscherichia coli
Sequence length477
FASTA sequence>sp|P69786|PTGCB_ECOLI PTS system glucose-specific EIICB component OS=Escherichia coli (strain K12) GN=ptsG PE=1 SV=1 MFKNAFANLQKVGKSLMLPVSVLPIAGILLGVGSANFSWLPAVVSHVMAEAGGSVFANMPLIFAIGVALGFTNNDGVSALAAVVAYGIMVKTMAVVAPLVLHLPAEEIASKHLADTGVLGGIISGAIAAYMFNRFYRIKLPEYLGFFAGKRFVPIISGLAAIFTGVVLSFIWPPIGSAIQTFSQWAAYQNPVVAFGIYGFIERCLVPFGLHHIWNVPFQMQIGEYTNAAGQVFHGDIPRYMAGDPTAGKLSGGFLFKMYGLPAAAIAIWHSAKPENRAKVGGIMISAALTSFLTGITEPIEFSFMFVAPILYIIHAILAGLAFPICILLGMRDGTSFSHGLIDFIVLSGNSSKLWLFPIVGIGYAIVYYTIFRVLIKALDLKTPGREDATEDAKATGTSEMAPALVAAFGGKENITNLDACITRLRVSVADVSKVDQAGLKKLGAAGVVVAGSGVQAIFGTKSDNLKTEMDEYIRNH
Structure Information
PDB ID1IBA
Quaternary structure
Function 1
Function descriptionphosphorylates glucose, enzyme sugars are phosphorylated during transport through the channel subunit of the protein complex
References for functionNuoffer, Claude, Bettina Zanolari, and B. Erni. "Glucose permease of Escherichia coli. The effect of cysteine to serine mutations on the function, stability, and regulation of transport and phosphorylation." Journal of Biological Chemistry 263.14 (1988): 6647-6655.
E.C. number2.7.1.69
Location of functional site(s)active site: 421
Cellular location of functionintegral membrane protein, plasma membrane
Comments
Function 2
Function descriptionIIB subunit binds and sequesters Mlc transcription repressor in presence of glucose
References for functionTanaka Y, Kimata K, Aiba H. A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc. EMBO J. 2000 Oct 16. PMID: 11032802
E.C. numberN/A
Location of functional site(s)
Cellular location of functionplasma membrane, integral membrane protein
Comments