Protein Information

General Information
MoonProt ID216
First appeared in release1.0
Name(s)Sarcosine oxidase, alpha subunit SOX
UniProt IDQ5JFD7 (Q5JFD7_THEKO), Unreviewed
GO termsGO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0003954 NADH dehydrogenase activity
Organisms for which functions have been demonstratedThermococcus kodakarensis
Sequence length492
FASTA sequence>tr|Q5JFD7|Q5JFD7_THEKO Sarcosine oxidase, alpha subunit OS=Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=TK0116 PE=4 SV=1 MRPLDLTEKDPSKKITIYLDGEPYEAYEGEKFPVAMLANGVYWLTTSNEGRHRGAFTFGPVPVTVNGVKNINGRKLKLKDGMKIERQRYDEFQEQVEIDEGKPVLRYVVDVAVIGAGPAGLGVVEEIGGKLTVALIEEKGWLGGDMWLKGVEQEGFGNPREAIERLTNFPENVRVFLKTAALGVYDKGEYFLVPAVRNDQLIEFMAKKVVLATGAVDNIMLFENNDWPGVFRRADALEVMNVWGVAPGRKVAVTGAFPEEITAELERWGIEYIIVPNVKRVEGEDRIERVIDENGNVYEVDALIMADGRIPDINPITQAGGKLRFKRGYYMPILDDEHRIRDGIYVAGSAVSIKPHYANYLEGKLVGAYILREFGYESEPCIYEERLKEYEPVARPVPKLPLDNFNGEDVQICGCGVTLKKVDDVVRSGITDLQIIKRLTHLAMGFCQGRFCLFNGALLVSQRSGMGMDRLDIPVARPPIKNVKMKVVAGRD
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionSarcosine oxidase, enzyme oxidation of the methyl group in sarcosine and transfer to folate oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate
References for functionLee S, Jia B, Pham BP, Shao Y, Kwak JM, Cheong GW. Architecture and characterization of sarcosine oxidase from Thermococcus kodakarensis KOD1. Extremophiles. 2012 Jan. PMID: 22083128
E.C. number1.5.3.1
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionNADH dehydrogenase NADH + H+ + acceptor <=> NAD+ + reduced acceptor
References for functionLee S, Jia B, Pham BP, Shao Y, Kwak JM, Cheong GW. Architecture and characterization of sarcosine oxidase from Thermococcus kodakarensis KOD1. Extremophiles. 2012 Jan. PMID: 22083128
E.C. number 1.6.99.3
Location of functional site(s)
Cellular location of functioncytoplasm
Comments