Protein Information

General Information
MoonProt ID22
First appeared in release1.0
Name(s)Elongation factor Tu EF-Tu Gene Name: tuf
UniProt IDQ74JU6 (EFTU_LACJO), Reviewed
GO termsGO:0006184 GTP catabolic process GO:0006412 translation GO:0006414 translational elongation GO:0000166 nucleotide binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005525 GTP binding GO:0005622 intracellular GO:0005737 cytoplasm GO: 0098631 cell adhesion mediator activity GO: 0005515 protein binding
Organisms for which functions have been demonstratedLactobacillus johnsonii NCC533 (La1)
Sequence length396
FASTA sequence>sp|Q74JU6|EFTU_LACJO Elongation factor Tu OS=Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) GN=tuf PE=3 SV=1 MAEKEHYERTKPHVNIGTIGHVDHGKTTLTAAITTVLAEDGLAQAEDYSQIDAAPEEKERGITINTAHVEYETKNRHYAHMDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVQYIVVFLNKVDLVDDPELIDLVEMEVRDLLSEYDYPGDDVPVIRGSALKALEGDPEQQDVIRKLMETVDEYIPTPERDTDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDEVEIVGLTDKIEKSTVTGLEMFHKTLDLGEAGDNVGVLLRGIDRDQVERGQVLAAPGSIQTHKNFKGQVYILNKDEGGRHTPFFSDYRPQFYFHTTDVTGKIELPEGTEMVMPGDNVEFTVELIKPVAIEKGTKFTIREGGKTVGAGQVTEILD
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionelongation factor in protein synthesis
References for functionduring protein biosynthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes
E.C. numberN/A
Location of functional site(s)Nucleotide binding site:137-140,20-27,82-86
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionattachment to human cells and mucins
References for functionGranato D, Bergonzelli GE, Pridmore RD, Marvin L, Rouvet M, Corth?syTheulaz IE. Cell surface-associated elongation factor Tu mediates the attachment of Lactobacillus johnsonii NCC533 (La1) to human intestinal cells and mucins. Infect Immun. 2004 Apr;72(4):2160-9. PMID: 15039339
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments