Protein Information

General Information
MoonProt ID223
First appeared in release1.0
Name(s)Serine hydroxymethyltransferase, cytosolic SHMT Glycine hydroxymethyltransferase Serine methylase Gene Name:SHMT1
UniProt IDP34896 (GLYC_HUMAN), Reviewed
GO termsGO:0006544 glycine metabolic process GO:0006545 glycine biosynthetic process GO:0006563 L-serine metabolic process GO:0006565 L-serine catabolic process GO:0006730 one-carbon metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0009113 purine nucleobase biosynthetic process GO:0019264 glycine biosynthetic process from serine GO:0034641 cellular nitrogen compound metabolic process GO:0035999 tetrahydrofolate interconversion GO:0044281 small molecule metabolic process GO:0045329 carnitine biosynthetic process GO:0046655 folic acid metabolic process GO:0051262 protein tetramerization GO:0051289 protein homotetramerization GO:0003824 catalytic activity GO:0004372 glycine hydroxymethyltransferase activity GO:0008732 L-allo-threonine aldolase activity GO:0016597 amino acid binding GO:0016740 transferase activity GO:0030170 pyridoxal phosphate binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005829 cytosol GO:0070062 extracellular vesicular exosome GO:0006412 translation GO:0003729 mRNA binding GO:0048027 mRNA 5-UTR binding
Organisms for which functions have been demonstratedHomo sapiens
Sequence length483
FASTA sequence>sp|P34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens GN=SHMT1 PE=1 SV=1 MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
Structure Information
PDB ID1BJ4
Quaternary structure
Function 1
Function descriptionserine hydroxymethyltransferase, enzyme 5,10-methylenetetrahydrofolate + glycine + H2O <=> tetrahydrofolate + L-serine One-carbon metabolism, tetrahydrofolate interconversion
References for functionCHAVE, Karen J., Keith SNELL, and Peter G. SANDERS. "Isolation and characterisation of human genomic sequences encoding cytosolic serine hydroxymethyltransferase." Biochemical Society Transactions 25.1 (1997): 53S-53S.
E.C. number2.1.2.1
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds mRNA binds the 5' untranslated region (UTR) of its own mRNA
References for functionLiu X, Reig B, Nasrallah IM, Stover PJ. Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein. Biochemistry. 2000 Sep 26. PMID: 10995219
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments