Protein Information

General Information
MoonProt ID226
First appeared in release1.0
Name(s)Mevalonate kinase MK cytosolic luteinizing hormone binding protein LHBP-1 Gene Name:Mvk
UniProt IDP17256 (KIME_RAT), Reviewed
GO termsGO:0006629 lipid metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0006720 isoprenoid metabolic process GO:0008152 metabolic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008299 isoprenoid biosynthetic process GO:0016125 sterol metabolic process GO:0016126 sterol biosynthetic process GO:0016310 phosphorylation GO:0017148 negative regulation of translation GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0045540 regulation of cholesterol biosynthetic process GO:0000166 nucleotide binding GO:0003729 mRNA binding GO:0004496 mevalonate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0005737 cytoplasm GO:0005777 peroxisome GO:0005829 cytosol GO:0003723 RNA binding GO:0003729 mRNA binding
Organisms for which functions have been demonstratedRattus norvegicus
Sequence length395
FASTA sequence>sp|P17256|KIME_RAT Mevalonate kinase OS=Rattus norvegicus GN=Mvk PE=1 SV=1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL
Structure Information
PDB ID1KVK 2R42
Quaternary structure
Function 1
Function descriptionMevalonate kinase, enzyme ATP + (R)-mevalonate => ADP + (R)-5-phosphomevalonate Isoprenoid biosynthesis, mevalonate pathway
References for functionTanaka, Richard D., et al. "Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver." Proceedings of the National Academy of Sciences 87.8 (1990): 2872-2876.
E.C. number2.7.1.36
Location of functional site(s)binding site: 55, 104, 108, 135; active site: 204; nucleotide binding: 138-148
Cellular location of functionperoxisome
Comments
Function 2
Function descriptionmRNA binding cytosolic luteinizing hormone receptor mRNA binding protein increases LH receptor mRNA degradation
References for functionNair AK, Kash JC, Peegel H, Menon KM. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. J Biol Chem. 2002 Jun 14. PMID: 11940568. Kash JC, Menon KM. Sequence-specific binding of a hormonally regulated mRNA binding protein to cytidine-rich sequences in the lutropin receptor open reading frame. Biochemistry. 1999 Dec 21. PMID: 10606523. Kash JC, Menon KM. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mrna binding during receptor down-regulation. J Biol Chem. 1998 Apr 24. PMID: 9553128.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments