Protein Information

General Information
MoonProt ID230
First appeared in release1.0
Name(s)60 kDa chaperonin 1 GroEL1 GroEL protein 1 Cpn60.1 Protein Cpn60-1 Gene Name: groEL1
UniProt IDP9WPE9 (CH601_MYCTU), Reviewed
GO termsGO:0006457 protein folding GO:0042026 protein refolding GO:0044267 cellular protein metabolic process GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0051082 unfolded protein binding GO:0005737 cytoplasm GO:0003677 DNA binding GO:0009295 nucleoid GO:0061598 molybdopterin adenylytransferase activity
Organisms for which functions have been demonstratedMycobacterium tuberculosis
Sequence length539
FASTA sequence>sp|P9WPE9|CH601_MYCTU 60 kDa chaperonin 1 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=groEL1 PE=1 SV=1 MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionprotein chaperone prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides
References for functionShinnick, THOMAS M., M. H. Vodkin, and J. C. Williams. "The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein." Infection and immunity 56.2 (1988): 446-451.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds DNA low specificity but high affinity nucleoid-associated protein condenses DNA into a compact structure
References for functionBasu D, Khare G, Singh S, Tyagi A, Khosla S, Mande SC. A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL. Nucleic Acids Res. 2009 Aug. PMID: 19528065
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleoid
Comments