Protein Information

General Information
MoonProt ID231
First appeared in release1.0
Name(s)Gephyrin Molybdopterin adenylyltransferase MPT adenylyltransferase Molybdopterin molybdenumtransferase MPT Mo-transferase Gene Name: GPHN
UniProt IDQ9NQX3 (GEPH_HUMAN), Reviewed
GO termsGO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0007529 establishment of synaptic specificity at neuromuscular junction GO:0008152 metabolic process GO:0032324 molybdopterin cofactor biosynthetic process GO:0044281 small molecule metabolic process GO:0000166 nucleotide binding GO:0003824 catalytic activity GO:0005524 ATP binding GO:0016740 transferase activity GO:0046872 metal ion binding GO:0061598 molybdopterin adenylyltransferase activity GO:0061599 molybdopterin molybdotransferase activity GO:0005622 intracellular GO:0005737 cytoplasm GO:0005856 cytoskeleton GO:0005886 plasma membrane GO:0016020 membrane GO:0030054 cell junction GO:0045202 synapse GO:0045211 postsynaptic membrane
Organisms for which functions have been demonstratedHomo sapiens
Sequence length736
FASTA sequence>sp|Q9NQX3|GEPH_HUMAN Gephyrin OS=Homo sapiens GN=GPHN PE=1 SV=1 MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
Structure Information
PDB ID1T3E 2FU3 2FTS 1IHC 1JLJ
Quaternary structure
Function 1
Function descriptionconnects membrane proteins to cytoskeleton microtubule binding protein anchors transmembrane receptors needed for clustering of inhibitory glycine receptors in postsynaptic membranes in the rat central nervous system
References for functionDavid-Watine, B. "The human gephyrin (GPHN) gene: structure, chromosome localization and expression in non-neuronal cells." Gene 271.2 (2001): 239-245.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasmic side of plasma membrane
Comments
Function 2
Function descriptionMolybdopterin adenylyltransferase and Molybdopterin molybdenumtransferase, enzyme biosynthesis of the molybdenum cofactor catalyzes two steps ATP + molybdopterin => diphosphate + adenylyl-molybdopterin. Adenylyl-molybdopterin + molybdate => molybdenum cofactor + AMP. Cofactor biosynthesis, molybdopterin biosynthesis
References for functionStallmeyer B, Schwarz G, Schulze J, Nerlich A, Reiss J, Kirsch J, Mendel RR. The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc Natl Acad Sci U S A. 1999 Feb 16. PMID: 9990024
E.C. number2.7.7.75 and 2.10.1.1
Location of functional site(s)
Cellular location of functioncytoplasm
Comments