Protein Information

General Information
MoonProt ID232
First appeared in release1.0
Name(s)Cytochrome c Gene Name: CYCS
UniProt IDP00004 (CYC_HORSE), Reviewed
GO termsGO:0006309 apoptotic DNA fragmentation GO:0006915 apoptotic process GO:0055114 oxidation-reduction process GO:0005506 iron ion binding GO:0009055 electron carrier activity GO:0020037 heme binding GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity GO:0046872 metal ion binding GO:0005739 mitochondrion GO:0005758 mitochondrial intermembrane space GO:0005829 cytosol GO:0070469 respiratory chain GO:0005515 protein binding
Organisms for which functions have been demonstratedEquus caballus (Horse)
Sequence length105
FASTA sequence>sp|P00004|CYC_HORSE Cytochrome c OS=Equus caballus GN=CYCS PE=1 SV=2 MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE
Structure Information
PDB ID1U75 1AKK 1FI7 1FI9 1I5T 1LC1 1LC2 1OCD 2FRC 2GIW 3NBS 3NBT 3WC8 2PCB 1CRC 1HRC 3O1Y 3O20 1WEJ 1GIW
Quaternary structure
Function 1
Function descriptionElectron carrier protein component of the mitochondrial electron-transport chain
References for functionMargoliash, E., et al. "Amino-acid sequence of horse heart cytochrome c: The complete amino-acid sequence." Nature192.4808 (1961): 1125-1127.
E.C. numberN/A
Location of functional site(s)binding site: 15, 18; metal binding: 19, 81
Cellular location of functionmitochondrion
Comments
Function 2
Function descriptionbinding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins
References for functionYu T, Wang X, PurringKoch C, Wei Y, McLendon GL. A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1. J Biol Chem. 2001 Apr 20. PMID: 11112785. Lim ML, Lum MG, Hansen TM, Roucou X, Nagley P. On the release of cytochrome c from mitochondria during cell death signaling. J Biomed Sci. 2002 0. PMID: 12372987.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments