Protein Information

General Information
MoonProt ID233
First appeared in release1.0
Name(s)Cytochrome c iso-1 Gene Name: CYC1
UniProt IDP00044 (CYC1_YEAST), Reviewed
GO termsGO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c GO:0006123 mitochondrial electron transport, cytochrome c to oxygen GO:0055114 oxidation-reduction process GO:0005506 iron ion binding GO:0005515 protein binding GO:0009055 electron carrier activity GO:0020037 heme binding GO:0046872 metal ion binding GO:0005739 mitochondrion GO:0005758 mitochondrial intermembrane space GO:0070469 respiratory chain GO:0005515 protein binding
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length109
FASTA sequence>sp|P00044|CYC1_YEAST Cytochrome c iso-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYC1 PE=1 SV=2 MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE
Structure Information
PDB ID2PCC, 2GB8, 2B12, 2JTI, 1KYO, 3CX5, 1YCC, 2B0Z, 2B11, 1U74, 2BCN, 1NMI, 2HV4, 2ORL, 3TYI, 2B10, 1YIC, 1YCC, 1CRH, 1CSW, 1IRV, 1CTY, 1CTZ, 1CHH, 1JQR
Quaternary structure
Function 1
Function descriptionElectron carrier protein component of the mitochondrial electron-transport chain
References for functionSadler, Ingrid, et al. "Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence." The EMBO journal 3.9 (1984): 2137.
E.C. numberN/A
Location of functional site(s)binding site: 20, 23; metal binding: 24, 86
Cellular location of functionmitochondrion
Comments
Function 2
Function descriptionbinding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins
References for functionYu T, Wang X, PurringKoch C, Wei Y, McLendon GL. A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1. J Biol Chem. 2001 Apr 20. PMID: 11112785. Lim ML, Lum MG, Hansen TM, Roucou X, Nagley P. On the release of cytochrome c from mitochondria during cell death signaling. J Biomed Sci. 2002 0. PMID: 12372987.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments