Protein Information

General Information
MoonProt ID238
First appeared in release1.0
Name(s)Glutaminyl-tRNA synthetase Glutamine-tRNA ligase GlnRS Gene Name: QARS
UniProt IDP47897 (SYQ_HUMAN), Reviewed
GO termsGO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006425 glutaminyl-tRNA aminoacylation GO:0010467 gene expression GO:0043039 tRNA aminoacylation GO:0000166 nucleotide binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004819 glutamine-tRNA ligase activity GO:0005524 ATP binding GO:0016874 ligase activity GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GO:0005737 cytoplasm GO:0005759 mitochondrial matrix GO:0005829 cytosol GO:0005515 protein binding GO:0043066 negative regulation of apoptotic process
Organisms for which functions have been demonstratedHomo sapiens
Sequence length775
FASTA sequence>sp|P47897|SYQ_HUMAN Glutamine--tRNA ligase OS=Homo sapiens GN=QARS PE=1 SV=1 MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLASRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPEQIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPKLEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionGlutaminyl-tRNA synthetase, enzyme ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln) protein synthesis
References for functionBrown, James R., and W. Ford Doolittle. "Gene descent, duplication, and horizontal transfer in the evolution of glutamyl-and glutaminyl-tRNA synthetases." Journal of molecular evolution49.4 (1999): 485-495.
E.C. number6.1.1.18
Location of functional site(s)binding site: 303, 438, 457; nucleotide binding: 271-273, 277-283, 486-487, 494-496
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioninteracts with ASK1 (Fas ligation activated apoptosis signal-regulating kinase 1) to inhibit apoptosis induced by ASK1 protein-protein interaction increased under conditions of increased glutamine concentration
References for functionKo YG, Kim EY, Kim T, Park H, Park HS, Choi EJ, Kim S. Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J Biol Chem. 2001 Feb 23. PMID: 11096076
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments