Protein Information

General Information
MoonProt ID24
First appeared in release1.0
Name(s)Ef-Tu elongation factor Tuf Elongation factor Tu Gene Name: tufB
UniProt IDP09591
GO termsGO:0006184 GTP catabolic process GO:0006412 translation GO:0006414 translational elongation GO:0000166 nucleotide binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005525 GTP binding GO:0005622 intracellular GO:0005737 cytoplasm GO: 0005515 protein binding
Organisms for which functions have been demonstratedPseudonomas aeruginosa
Sequence length397
FASTA sequence>sp|P09591|EFTU_PSEAE Elongation factor Tu OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) GN=tufA PE=1 SV=2 MAKEKFERNKPHVNVGTIGHVDHGKTTLTAALTKVCSDTWGGSARAFDQIDNAPEEKARGITINTSHVEYDSAVRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKADMVDDAELLELVEMEVRDLLNTYDFPGDDTPIIIGSALMALEGKDDNGIGVSAVQKLVETLDSYIPEPVRAIDQPFLMPIEDVFSISGRGTVVTGRVERGIIKVQEEVEIVGIKATTKTTCTGVEMFRKLLDEGRAGENVGILLRGTKREDVERGQVLAKPGTIKPHTKFECEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGNCELPEGVEMVMPGDNIKMVVTLIAPIAMEDGLRFAIREGGRTVGAGVVAKIIE
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionelongation factor during protein synthesis during protein synthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes
References for functionMukhopadhyay, Subhendu, et al. "Complex formation of the elongation factor Tu from Pseudomonas aeruginosa with nucleoside diphosphate kinase modulates ribosomal GTP synthesis and peptide chain elongation." Journal of Biological Chemistry 272.28 (1997): 17815-17820.
E.C. numberN/A
Location of functional site(s)Nucleotide binding site:19-26,136-139,81-85
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionfactor H and plasminogen binding
References for functionKunert A, Losse J, Gruszin C, H?hn M, Kaendler K, Mikkat S, Volke D, Hoffmann R, Jokiranta TS, Seeberger H, Moellmann U, Hellwage J, Zipfel PF. Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein. J Immunol. 2007 Sep 1;179(5):2979-88. PMID: 17709513
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments