Protein Information

General Information
MoonProt ID240
First appeared in release1.0
Name(s)Tryptophanyl-tRNA synthetase Tryptophan--tRNA ligase, cytoplasmic Interferon-induced protein 53 IFP53 TrpRS hWRS Gene Name: WARS
UniProt IDP23381 (SYWC_HUMAN), Reviewed
GO termsGO:0001525 angiogenesis GO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0005515 protein binding GO:0006436 tryptophanyl-tRNA aminoacylation GO:0008285 negative regulation of cell proliferation GO:0010467 gene expression GO:0045765 regulation of angiogenesis GO:0000166 nucleotide binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004830 tryptophan-tRNA ligase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016874 ligase activity GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0070062 extracellular vesicular exosome
Organisms for which functions have been demonstratedHomo sapiens
Sequence length471
FASTA sequence>sp|P23381|SYWC_HUMAN Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens GN=WARS PE=1 SV=2 MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ
Structure Information
PDB ID2QUI, 2QUJ, 2QUK, 2QUH, 2AZX, 1R6T, 1R6U, 1ULH, 1O5T, 2AKE, 2DR2, 2QUJ
Quaternary structure
Function 1
Function descriptionTryptophanyl-tRNA synthetase, enzyme ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + L-tryptophyl-tRNA(Trp) protein synthesis
References for functionRubin, Berish Y., et al. "Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts." Journal of Biological Chemistry 266.36 (1991): 24245-24248.
E.C. number6.1.1.2
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionforms complex with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and poly(ADP-ribose) polymerase 1 (PARP-1) the complex activates p53
References for functionSajish M, Zhou Q, Kishi S, Valdez DM, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN- and p53 signaling. Nat Chem Biol. 2012 Apr 15. PMID: 22504299
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments