Protein Information

General Information
MoonProt ID241
First appeared in release1.0
Name(s)Multisynthase complex auxiliary component p43 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Gene Name: Aimp1
UniProt IDP31230 (AIMP1_MOUSE), Reviewed
GO termsGO:0001525 angiogenesis GO:0001937 negative regulation of endothelial cell proliferation GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006412 translation GO:0006915 apoptotic process GO:0006954 inflammatory response GO:0007155 cell adhesion GO:0007267 cell-cell signaling GO:0050900 leukocyte migration GO:0000049 tRNA binding GO:0003723 RNA binding GO:0005125 cytokine activity GO:0042803 protein homodimerization activity GO:0005576 extracellular region GO:0005615 extracellular space GO:0005634 nucleus GO:0005737 cytoplasm GO:0005783 endoplasmic reticulum GO:0005794 Golgi apparatus GO:0005829 cytosol GO:0009986 cell surface GO:0017101 aminoacyl-tRNA synthetase multienzyme complex GO:0030133 transport vesicle GO:0031410 cytoplasmic vesicle GO:0005125 cytokine activity GO:0001525 angiogenesis
Organisms for which functions have been demonstratedMus musculus
Sequence length310
FASTA sequence>sp|P31230|AIMP1_MOUSE Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Mus musculus GN=Aimp1 PE=1 SV=2 MATNDAVLKRLEQKGAEADQIIEYLKQQVALLKEKAILQATMREEKKLRVENAKLKKEIEELKQELILAEIHNGVEQVRVRLSTPLQTNCTASESVVQSPSVATTASPATKEQIKAGEEKKVKEKTEKKGEKKEKQQSAAASTDSKPIDASRLDLRIGCIVTAKKHPDADSLYVEEVDVGEAAPRTVVSGLVNHVPLEQMQNRMVVLLCNLKPAKMRGVLSQAMVMCASSPEKVEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNAECVATYKGAPFEVKGKGVCRAQTMANSGIK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p18
References for functionQuevillon, Sophie, et al. "The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine." Journal of Biological Chemistry 272.51 (1997): 32573-32579.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioncytokine roles in angiogenesis - inducing endothelial cell migration induces maturation of dendritic cells induces monocyte cell adhesion
References for functionPark SG, Choi EC, Kim S. Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis. IUBMB Life. 2010 Apr. PMID: 20306515
E.C. numberN/A
Location of functional site(s)
Cellular location of functionsecreted
Comments