Protein Information

General Information
MoonProt ID245
First appeared in release1.0
Name(s)Methionyl-tRNA synthetase Methionine--tRNA ligase, cytoplasmic MetRS Gene Name: MARS
UniProt IDP56192 (SYMC_HUMAN), Reviewed
GO termsGO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006431 methionyl-tRNA aminoacylation GO:0010467 gene expression GO:0000049 tRNA binding GO:0000166 nucleotide binding GO:0003723 RNA binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004825 methionine-tRNA ligase activity GO:0005524 ATP binding GO:0016874 ligase activity GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005829 cytosol GO:0070062 extracellular vesicular exosome GO:0016072 rRNA metabolic process GO:0005730 nucleolus GO:0042254 ribosome biogenesis
Organisms for which functions have been demonstratedHomo sapiens
Sequence length900
FASTA sequence>sp|P56192|SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=MARS PE=1 SV=2 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionMethionyl-tRNA synthetase, enzyme ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met) protein synthesis
References for functionLage, Hermann, and Manfred Dietel. "Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase." Gene 178.1 (1996): 187-189.
E.C. number6.1.1.10
Location of functional site(s)binding site: 596
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbiogenesis of rRNA in nucleoli translocation to nucleolus triggered by growth factors
References for functionKo YG, Kang YS, Kim EK, Park SG, Kim S. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J Cell Biol. 2000 May 1. PMID: 10791971
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus, nucleolus
Comments