Protein Information

General Information
MoonProt ID249
First appeared in release1.0
Name(s)Protein argonaute 4 Protein overexpressor of cationic peroxidase II Gene Name: AGO4
UniProt IDQ9ZVD5 (AGO4_ARATH), Reviewed
GO termsGO:0000023 maltose metabolic process GO:0000226 microtubule cytoskeleton organization GO:0000278 mitotic cell cycle GO:0000724 double-strand break repair via homologous recombination GO:0000911 cytokinesis by cell plate formation GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006275 regulation of DNA replication GO:0006306 DNA methylation GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006417 regulation of translation GO:0006952 defense response GO:0007267 cell-cell signaling GO:0008283 cell proliferation GO:0009555 pollen development GO:0009616 virus induced gene silencing GO:0009816 defense response to bacterium, incompatible interaction GO:0009855 determination of bilateral symmetry GO:0009909 regulation of flower development GO:0009965 leaf morphogenesis GO:0010014 meristem initiation GO:0010073 meristem maintenance GO:0010267 production of ta-siRNAs involved in RNA interference GO:0016032 viral process GO:0016246 RNA interference GO:0016444 somatic cell DNA recombination GO:0016458 gene silencing GO:0016568 chromatin modification GO:0016569 covalent chromatin modification GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0019252 starch biosynthetic process GO:0030422 production of siRNA involved in RNA interference GO:0031047 gene silencing by RNA GO:0031048 chromatin silencing by small RNA GO:0034968 histone lysine methylation GO:0035196 production of miRNAs involved in gene silencing by miRNA GO:0043085 positive regulation of catalytic activity GO:0048449 floral organ formation GO:0051225 spindle assembly GO:0051567 histone H3-K9 methylation GO:0051726 regulation of cell cycle GO:0010495 long-distance posttranscriptional gene silencing GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding GO:0035197 siRNA binding GO:0005634 nucleus GO:0005719 nuclear euchromatin GO:0005730 nucleolus GO:0015030 Cajal body GO:0030529 ribonucleoprotein complex GO:0005829 cytosol GO:0030422 production of siRNA involved in RNA interference GO:0016070 RNA metabolic process GO:0016246 RNA interference GO:0004518 nuclease activity GO:0004540 ribonuclease activity
Organisms for which functions have been demonstratedArabidopsis thaliana
Sequence length924
FASTA sequence>sp|Q9ZVD5|AGO4_ARATH Protein argonaute 4 OS=Arabidopsis thaliana GN=AGO4 PE=1 SV=2 MDSTNGNGADLESANGANGSGVTEALPPPPPVIPPNVEPVRVKTELAEKKGPVRVPMARKGFGTRGQKIPLLTNHFKVDVANLQGHFFHYSVALFYDDGRPVEQKGVGRKILDKVHQTYHSDLDGKEFAYDGEKTLFTYGALPSNKMDFSVVLEEVSATRANGNGSPNGNESPSDGDRKRLRRPNRSKNFRVEISYAAKIPLQALANAMRGQESENSQEAIRVLDIILRQHAARQGCLLVRQSFFHNDPTNCEPVGGNILGCRGFHSSFRTTQGGMSLNMDVTTTMIIKPGPVVDFLIANQNARDPYSIDWSKAKRTLKNLRVKVSPSGQEFKITGLSDKPCREQTFELKKRNPNENGEFETTEVTVADYFRDTRHIDLQYSADLPCINVGKPKRPTYIPLELCALVPLQRYTKALTTFQRSALVEKSRQKPQERMTVLSKALKVSNYDAEPLLRSCGISISSNFTQVEGRVLPAPKLKMGCGSETFPRNGRWNFNNKEFVEPTKIQRWVVVNFSARCNVRQVVDDLIKIGGSKGIEIASPFQVFEEGNQFRRAPPMIRVENMFKDIQSKLPGVPQFILCVLPDKKNSDLYGPWKKKNLTEFGIVTQCMAPTRQPNDQYLTNLLLKINAKLGGLNSMLSVERTPAFTVISKVPTIILGMDVSHGSPGQSDVPSIAAVVSSREWPLISKYRASVRTQPSKAEMIESLVKKNGTEDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQFNQVLNIELDQIIEACKLLDANWNPKFLLLVAQKNHHTKFFQPTSPENVPPGTIIDNKICHPKNNDFYLCAHAGMIGTTRPTHYHVLYDEIGFSADELQELVHSLSYVYQRSTSAISVVAPICYAHLAAAQLGTFMKFEDQSETSSSHGGITAPGPISVAQLPRLKDNVANSMFFC
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionComponent of the RISC complex RNA-directed DNA methylation, involves small interfering RNA (siRNA) RNA-directed gene silencing
References for functionYamada, Kayoko, et al. "Empirical analysis of transcriptional activity in the Arabidopsis genome." Science 302.5646 (2003): 842-846.
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments
Function 2
Function descriptioncleaves RNA transcripts, enzyme generates small interfering RNAs (siRNAs)
References for functionQi Y, He X, Wang XJ, Kohany O, Jurka J, Hannon GJ. Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature. 2006 Oct 26. PMID: 16998468
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments