Protein Information

General Information
MoonProt ID25
First appeared in release1.0
Name(s)Enolase 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: eno
UniProt IDQ8GE63 (ENO_AERHY), Reviewed
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO: 0005515 protein binding
Organisms for which functions have been demonstratedAeromonas hydrophila
Sequence length433
FASTA sequence>gi|25989631|gb|AAN28926.1| enolase [Aeromonas hydrophila] MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKALEAVNGPIAQALLGKDAKDQATVDQIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYAHIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYKLGTDVTLAMDCAASEFYDAEKKEYNLKGEGRVFTSNGFSDFLEELTAKFPIVSIEDGLDESDWEGFAYQTQKLGKKIQIVGDDLFVTNTKILKRGIDNGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGAKAPFRGLKEVKNQA
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysis
References for function
E.C. number4.2.1.11
Location of functional site(s)Active site:209,343 Binding site:159,318,291,343,168,394 Metal binding site:246,291,318
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding (binds human plasminogen)
References for functionSha J, Erova TE, Alyea RA, Wang S, Olano JP, Pancholi V, Chopra AK. Surface-expressed enolase contributes to the pathogenesis of clinical isolate SSU of Aeromonas hydrophila. J Bacteriol. 2009 May;191(9):3095-107. doi: 10.1128/JB.00005-09. Epub 2009 Mar 6. PMID: 19270100
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments